Neurophysiological investigation of spontaneous correlated and anticorrelated fluctuations of the BOLD signal.
Neurophysiological investigation of spontaneous correlated and anticorrelated fluctuations of the BOLD signal.
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DOI：
10.1523/jneurosci.4837-12.2013
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发表时间：
2013-04-10
期刊：
影响因子：
--
通讯作者：
Mehta AD
中科院分区：
文献类型：
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作者：
Keller CJ;Bickel S;Honey CJ;Groppe DM;Entz L;Craddock RC;Lado FA;Kelly C;Milham M;Mehta AD
对内在fMRI BOLD信号波动的分析可靠地揭示了大脑中相关和反相关的功能网络。由于BOLD信号是神经元活动的间接测量，并且可以通过诸如全局信号回归（GSR）的预处理步骤引入相关关系，因此相关和相关BOLD波动的神经生理学意义是争论的来源。在这里，我们解决这个问题，通过检查相关的BOLD波动和相关波动的电生理高伽玛功率（HGP）信号直接从5例患者的皮层表面记录的空间组织之间的对应关系。我们表明，积极和消极的BOLD相关性神经生理相关性反映在自发神经元活动的波动。虽然将GSR应用于BOLD信号导致在ECoG数据中不明显的一些BOLD关系，但是它总体上增强了神经元-血流动力学对应。总之，这些研究结果提供了支持的神经生理保真度的BOLD相关性和神经元的关系。
Analyses of intrinsic fMRI BOLD signal fluctuations reliably reveal correlated and anticorrelated functional networks in the brain. Since the BOLD signal is an indirect measure of neuronal activity, and anticorrelations can be introduced by preprocessing steps such as global signal regression (GSR), the neurophysiological significance of correlated and anticorrelated BOLD fluctuations is a source of debate. Here, we address this question by examining the correspondence between the spatial organization of correlated BOLD fluctuations and correlated fluctuations in electrophysiological high gamma power (HGP) signals recorded directly from the cortical surface of 5 patients. We demonstrate that both positive and negative BOLD correlations have neurophysiological correlates reflected in fluctuations of spontaneous neuronal activity. Although applying GSR to BOLD signals results in some BOLD anticorrelations that are not apparent in the ECoG data, it enhances the neuronal-hemodynamic correspondence overall. Together, these findings provide support for the neurophysiological fidelity of BOLD correlations and anticorrelations.