Genetic variation, brain, and intelligence differences.
Genetic variation, brain, and intelligence differences.
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遗传变异、大脑和智力差异。
DOI：
10.1038/s41380-021-01027-y
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发表时间：
2022-01
影响因子：
11
通讯作者：
Hill WD
中科院分区：
文献类型：
--
作者：
Deary IJ;Cox SR;Hill WD
人类智力的个体差异，如使用认知测试分数评估，具有良好的复制，分层表型协方差结构。它们在整个生命过程中基本稳定，并可预测教育、社会和健康结果。从这种坚实的表型基础和对生命的重要性出发，人们对智力的环境、社会和遗传病因学，以及大脑结构和功能中智力差异的基础产生了兴趣。在这里，我们总结和批评了过去10年左右的分子遗传学（基于dna）对智力的研究，包括与智力相关的遗传位点的发现，基于dna的遗传性，以及智力与其他性状的遗传相关性。我们总结了新的脑成像智力发现，包括全脑关联和灰质和白质关联。我们总结了区域脑成像与智力的联系，并根据理论解释了这些联系。我们的研究结合了遗传学和脑成像来研究智力差异。在所有这些领域都有新的，虽然不太明显的联系，缺乏机械的解释。我们试图找出增长点，这些增长点可能有助于对某些个体间智力差异进行更综合的“系统生物学”解释。
Individual differences in human intelligence, as assessed using cognitive test scores, have a well-replicated, hierarchical phenotypic covariance structure. They are substantially stable across the life course, and are predictive of educational, social, and health outcomes. From this solid phenotypic foundation and importance for life, comes an interest in the environmental, social, and genetic aetiologies of intelligence, and in the foundations of intelligence differences in brain structure and functioning. Here, we summarise and critique the last 10 years or so of molecular genetic (DNA-based) research on intelligence, including the discovery of genetic loci associated with intelligence, DNA-based heritability, and intelligence’s genetic correlations with other traits. We summarise new brain imaging-intelligence findings, including whole-brain associations and grey and white matter associations. We summarise regional brain imaging associations with intelligence and interpret these with respect to theoretical accounts. We address research that combines genetics and brain imaging in studying intelligence differences. There are new, though modest, associations in all these areas, and mechanistic accounts are lacking. We attempt to identify growing points that might contribute toward a more integrated ‘systems biology’ account of some of the between-individual differences in intelligence.
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影响因子：
11
作者：
Davies G;Marioni RE;Liewald DC;Hill WD;Hagenaars SP;Harris SE;Ritchie SJ;Luciano M;Fawns-Ritchie C;Lyall D;Cullen B;Cox SR;Hayward C;Porteous DJ;Evans J;McIntosh AM;Gallacher J;Craddock N;Pell JP;Smith DJ;Gale CR;Deary IJ
通讯作者：
Deary IJ
影响因子：
3.5
作者：
通讯作者：
--
影响因子：
11
作者：
Davies G;Harris SE;Reynolds CA;Payton A;Knight HM;Liewald DC;Lopez LM;Luciano M;Gow AJ;Corley J;Henderson R;Murray C;Pattie A;Fox HC;Redmond P;Lutz MW;Chiba-Falek O;Linnertz C;Saith S;Haggarty P;McNeill G;Ke X;Ollier W;Horan M;Roses AD;Ponting CP;Porteous DJ;Tenesa A;Pickles A;Starr JM;Whalley LJ;Pedersen NL;Pendleton N;Visscher PM;Deary IJ
通讯作者：
Deary IJ
影响因子：
6.8
作者：
Corley, Janie;Cox, Simon R.;Deary, Ian J.
通讯作者：
Deary, Ian J.
对一般认知功能变异的遗传贡献：电荷联盟中全基因组关联研究的荟萃分析（n = 53949）。
影响因子：
11
作者：
Davies, G.;Armstrong, N.;Bis, J. C.;Bressler, J.;Chouraki, V.;Giddaluru, S.;Hofer, E.;Ibrahim-Verbaas, C. A.;Kirin, M.;Lahti, J.;van der Lee, S. J.;Le Hellard, S.;Liu, T.;Marioni, R. E.;Oldmeadow, C.;Postmus, I.;Smith, A. V.;Smith, J. A.;Thalamuthu, A.;Thomson, R.;Vitart, V.;Wang, J.;Yu, L.;Zgaga, L.;Zhao, W.;Boxall, R.;Harris, S. E.;Hill, W. D.;Liewald, D. C.;Luciano, M.;Adams, H.;Ames, D.;Amin, N.;Amouyel, P.;Assareh, A. A.;Au, R.;Becker, J. T.;Beiser, A.;Berr, C.;Bertram, L.;Boerwinkle, E.;Buckley, B. M.;Campbell, H.;Corley, J.;De Jager, P. L.;Dufouil, C.;Eriksson, J. G.;Espeseth, T.;Faul, J. D.;Ford, I.;Gottesman, R. F.;Griswold, M. E.;Gudnason, V.;Harris, T. B.;Heiss, G.;Hofman, A.;Holliday, E. G.;Huffman, J.;Kardia, S. L. R.;Kochan, N.;Knopman, D. S.;Kwok, J. B.;Lambert, J-C;Lee, T.;Li, G.;Li, S-C;Loitfelder, M.;Lopez, O. L.;Lundervold, A. J.;Lundqvist, A.;Mather, K. A.;Mirza, S. S.;Nyberg, L.;Oostra, B. A.;Palotie, A.;Papenberg, G.;Pattie, A.;Petrovic, K.;Polasek, O.;Psaty, B. M.;Redmond, P.;Reppermund, S.;Rotter, J. I.;Schmidt, H.;Schuur, M.;Schofield, P. W.;Scott, R. J.;Steen, V. M.;Stott, D. J.;Van Swieten, J. C.;Taylor, K. D.;Trollor, J.;Trompet, S.;Uitterlinden, A. G.;Weinstein, G.;Widen, E.;Windham, B. G.;Jukema, J. W.;Wright, A. F.;Wright, M. J.;Yang, Q.;Amieva, H.;Attia, J. R.;Bennett, D. A.;Brodaty, H.;de Craen, A. J. M.;Hayward, C.;Ikram, M. A.;Lindenberger, U.;Nilsson, L-G;Porteous, D. J.;Raikkonen, K.;Reinvang, I.;Rudan, I.;Sachdev, P. S.;Schmidt, R.;Schofield, P. R.;Srikanth, V.;Starr, J. M.;Turner, S. T.;Weir, D. R.;Wilson, J. F.;Van Duijn, C.;Launer, L.;Fitzpatrick, A. L.;Seshadri, S.;Mosley, T. H., Jr.;Deary, I. J.
通讯作者：
Deary, I. J.