Effect of age and other factors on macular pigment optical density measured with resonance Raman spectroscopy.
Effect of age and other factors on macular pigment optical density measured with resonance Raman spectroscopy.
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年龄和其他因素对共振拉曼光谱测量的黄斑色素光密度的影响。
DOI：
10.1007/s00417-014-2574-x
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
Ohira,Akihiro
中科院分区：
文献类型：
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作者：
Obana,Akira;Gohto,Yuko;Tanito,Masaki;Okazaki,Shigetoshi;Gellermann,Werner;Bernstein,PaulS;Ohira,Akihiro
研究背景黄斑色素是视网膜抵抗可见光损伤的防御系统。黄斑色素光密度（MPOD）水平是否随年龄增长而下降仍有争议，因为年龄效应取决于用于测量MPOD水平的技术。共振拉曼光谱（RRS）是测量MPOD的客观方法，使用RRS的研究显示MPOD水平与年龄相关的急剧下降;然而，由于RRS测量受白内障影响，因此有人认为RRS测量的年龄相关下降是老年受试者透镜变化的人为因素。在本研究中，MPOD水平测定与RRS在人工晶状体眼，年龄和其他因素对MPOD levels. MethodsSubjects的影响包括144例无眼底疾病谁接受白内障手术与untinted人工透镜植入。术后第1天使用积分RRS测量144只眼的MPOD水平。与MPOD水平潜在相关的因素如年龄、性别、吸烟习惯、体重指数、糖尿病、青光眼、眼轴长度、瞳孔直径、等效球镜屈光不正和中心凹厚度通过多元回归分析进行了检查。917（标准偏差[SD]）拉曼计数。多元回归分析显示，年龄和眼轴长度与低MPOD值显著相关（年龄的回归系数为-59，眼轴长度的回归系数为-404）。没有显着的相关性被观察到为其他factor.ConclusionsAfter删除潜在的混淆影响的年龄相关的透镜变黄的RRS测量，年龄仍然是一个显着的患者参数降低MPOD水平。MPOD水平每十年下降超过10%。轴向长度也是MPOD水平的负预测因子。由于本研究仅包括50岁及以上的患者，年龄和其他因素对年轻受试者MPOD水平的影响仍然未知。
BackgroundMacular pigment is a defense system against phototoxic damage of the retina by visible light. It is still under debate whether or not macular pigment optical density (MPOD) levels decline with age, because the age effect varied depending on the technique used to measure MPOD levels. Resonance Raman spectroscopy (RRS) is an objective method to measure MPOD, and studies using RRS showed a drastic age-related decline of MPOD levels; however, since RRS measurements are influenced by cataracts, it has been argued that the age-related decline of RRS measurements is an artifact from lens changes in aged subjects. In the present study, MPOD levels were measured with RRS in pseudophakic eyes, and the effects of age and other factors on MPOD levels were investigated.MethodsThe subjects included 144 patients with no fundus disorders who received cataract surgery with untinted intraocular lens implantation. MPOD levels were measured in 144 eyes using integral RRS 1 day post surgery. Factors potentially associated with MPOD levels such as age, gender, smoking habits, body mass index, diabetes, glaucoma, axial length, pupil diameter, spherical equivalent refractive error, and foveal thickness were examined by multiple regression analysis.ResultsThe macular pigment RRS levels ranged from 776 to 11,815 Raman counts, with an average level of 4,375 ± 1,917 (standard deviation [SD]) Raman counts. Multiple regression analysis revealed that age and axial length were significantly correlated with low MPOD values (regression coefficient of −59 for age and −404 for axial length, respectively). No significant correlations were observed for other factors.ConclusionsAfter removing the potentially confounding effect of age-related lens yellowing on the RRS measurements, age remained a significant patient parameter for lowered MPOD levels. MPOD levels were found to decline by more than 10 % each decade. Axial length was also a negative predictor of MPOD levels. Since the present study included only patients aged 50 years and older, the effects of age and other factors on MPOD levels for younger subjects remain unknown.