Palladium-Catalyzed C-H Perfluoroalkylation of Arenes
Palladium-Catalyzed C-H Perfluoroalkylation of Arenes
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DOI：
10.1021/ol200628n
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发表时间：
2011-05-20
期刊：
影响因子：
5.2
通讯作者：
Sanford, Melanie S.
中科院分区：
文献类型：
--
作者：
Loy, Rebecca N.;Sanford, Melanie S.
报道了钯催化的全氟烷基碘（RFI）与简单芳香底物的偶联反应。在膦配位的Pd催化剂存在下，以Cs_2CO_3为碱，以良好至优异的产率获得全氟烷基化芳烃产物。这些转换的发展，优化，范围和初步的机制研究的报告。
A new Pd-catalyzed reaction for the coupling between perfluoroalkyl Iodides (RFI) and simple aromatic substrates is described. The perfluoroalkylated arene products are obtained In good to excellent yields in the presence of a phosphine-ligated Pd catalyst and Cs2CO3 as a base. The development, optimization, scope, and preliminary mechanistic studies of these transformations are reported.