Effectiveness of BCG vaccination to aged mice.
Effectiveness of BCG vaccination to aged mice.
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DOI：
10.1186/1742-4933-7-12
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发表时间：
2010-09-01
期刊：
影响因子：
--
通讯作者：
Onozaki K
中科院分区：
文献类型：
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作者：
Ito T;Takii T;Maruyama M;Hayashi D;Wako T;Asai A;Horita Y;Taniguchi K;Yano I;Yamamoto S;Onozaki K
结核病新发病例数量仍在增加，据估计2010年将接近1000万例。全世界老年人的数量一直在增长。老龄化是结核病的危险因素之一，因为老年人的免疫反应下降。牛分枝杆菌卡介苗（BCG）是目前用于结核病的唯一疫苗，然而，卡介苗对成人的有效性仍存在争议。耐多药结核分枝杆菌（MDR-TB）的出现使我们重新认识到结核病疫苗接种的重要性。在这项研究中，我们评估了卡介苗接种对老年小鼠的疗效。接种卡介苗的老龄小鼠（24月龄）的Th1应答、干扰素-γ产生和白细胞介素2与幼龄小鼠（4至6周龄）相当。卡介苗对老年小鼠抗结核分枝杆菌H37Rv的保护作用与幼年小鼠相同。这些发现表明，老年人接种疫苗仍可有效预防结核病。
The tuberculosis (TB) still increases in the number of new cases, which is estimated to approach 10 million in 2010. The number of aged people has been growing all over the world. Ageing is one of risk factors in tuberculosis because of decreased immune responses in aged people. Mycobacterium bovis Bacillus Calmette Guérin (BCG) is a sole vaccine currently used for TB, however, the efficacy of BCG in adults is still a matter of debate. Emerging the multidrug resistant Mycobacterium tuberculosis (MDR-TB) make us to see the importance of vaccination against TB in new light. In this study, we evaluated the efficacy of BCG vaccination in aged mice. The Th1 responses, interferon-γ production and interleukin 2, in BCG inoculated aged mice (24-month-old) were comparable to those of young mice (4- to 6-week-old). The protection activity of BCG in aged mice against Mycobacterium tuberculosis H37Rv was also the same as young mice. These findings suggest that vaccination in aged generation is still effective for protection against tuberculosis.