Robust Increase in Supply by Vessel Dilation in Globally Coupled Microvasculature
Robust Increase in Supply by Vessel Dilation in Globally Coupled Microvasculature
复制标题
DOI：
10.1103/physrevlett.123.228103
复制
发表时间：
2019-11-26
影响因子：
8.6
通讯作者：
Alim, Karen
中科院分区：
文献类型：
--
作者：
Meigel, Felix J.;Cha, Peter;Alim, Karen
神经元活动通过局部扩张脑微血管系统中的血管来诱导血流变化。考虑到血流在微血管系统内是全局耦合的，单根血管的局部扩张如何增加基于血流的代谢物供应？求解大鼠脑微血管的供应动力学，我们发现一个参数制度占主导地位的生理。这种制度允许独立于网络中的位置的供应的强劲增长，我们对此进行了分析。我们发现，局部耦合的血管促进空间相关的增加供应扩张。
Neuronal activity induces changes in blood flow by locally dilating vessels in the brain microvasculature. How can the local dilation of a single vessel increase flow-based metabolite supply, given that flows are globally coupled within microvasculature? Solving the supply dynamics for rat brain microvasculature, we find one parameter regime to dominate physiologically. This regime allows for robust increase in supply independent of the position in the network, which we explain analytically. We show that local coupling of vessels promotes spatially correlated increased supply by dilation.