p53 in the DNA-Damage-Repair Process.
p53 in the DNA-Damage-Repair Process.
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DOI：
10.1101/cshperspect.a026070
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发表时间：
2016-05-02
影响因子：
5.4
通讯作者：
Schumacher B
中科院分区：
文献类型：
--
作者：
Williams AB;Schumacher B
人体内的细胞不断受到各种基因毒性攻击的挑战。DNA的错误修复会导致突变和染色体畸变，从而改变肿瘤抑制基因或致癌基因的功能，从而导致癌症的发展。作为一个中心肿瘤抑制因子，p53通过协调多种DNA损伤反应（DDR）机制来保护基因组。早在后生动物进化的早期，p53就开始控制基因组受损细胞的凋亡。p53作为DNA修复的推动者发挥着重要作用，它可以停止细胞周期，让修复机制有时间恢复基因组的稳定性。此外，p53发挥着多种作用，也直接影响着各种DNA修复系统的活性。因此，p53似乎是通过维持基因组的稳定性来防止癌症发展的多重任务。
The cells in the human body are continuously challenged by a variety of genotoxic attacks. Erroneous repair of the DNA can lead to mutations and chromosomal aberrations that can alter the functions of tumor suppressor genes or oncogenes, thus causing cancer development. As a central tumor suppressor, p53 guards the genome by orchestrating a variety of DNA damage response (DDR) mechanisms. Already early in metazoan evolution, p53 started controlling the apoptotic demise of genomically compromised cells. p53 plays a prominent role as a facilitator of DNA repair by halting the cell cycle to allow time for the repair machineries to restore genome stability. In addition, p53 took on diverse roles to also directly impact the activity of various DNA repair systems. It thus appears as if p53 is multitasking in protecting from cancer development by maintaining genome stability.