Nonclassical patrolling monocyte function in the vasculature.
Nonclassical patrolling monocyte function in the vasculature.
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DOI：
10.1161/atvbaha.114.304650
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发表时间：
2015-06
期刊：
影响因子：
--
通讯作者：
Hanna RN
中科院分区：
文献类型：
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作者：
Thomas G;Tacke R;Hedrick CC;Hanna RN
非经典巡逻单核细胞的特点是其独特的能力，主动巡逻的血管内皮细胞在动态平衡和炎症条件下。巡逻单核细胞亚群(小鼠CX3CR1HighLy6C−和人类CX3CR1HighCD14dimCD16+)不同于经典单核细胞亚群(小鼠CCR2HighLy6C+和人类CCR2HighCD14+CD16−)，在血管系统和炎症性疾病中具有独特的功能。巡逻单核细胞在许多疾病环境中发挥作用，从血管系统中清除受损细胞和碎片，并与伤口愈合和受损组织中炎症的消退有关。这篇综述强调了这些巡逻的单核细胞在血管系统和炎症过程中的独特功能。
Nonclassical patrolling monocytes are characterized by their unique ability to actively patrol the vascular endothelium under homeostatic and inflammatory conditions. Patrolling monocyte subsets (CX3CR1highLy6C− in mouse, and CX3CR1highCD14dimCD16+ in humans) are distinct from the classical monocyte subsets (CCR2highLy6C+ in mouse, and CCR2highCD14+CD16− in humans) and exhibit unique functions in the vasculature and inflammatory disease. Patrolling monocytes function in a number of disease settings to remove damaged cells and debris from the vasculature, and have been associated with wound healing and the resolution of inflammation in damaged tissues. This review highlights the unique functions of these patrolling monocytes in the vasculature and during inflammation.