Several genetic variants associated with systemic sclerosis in a Chinese Han population
Several genetic variants associated with systemic sclerosis in a Chinese Han population
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DOI：
10.1007/s10067-022-06409-3
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发表时间：
2022-10-27
影响因子：
3.4
通讯作者：
Li，Yongzhe
中科院分区：
文献类型：
--
作者：
Liu，Chenxi;Yan，Songxin;Li，Yongzhe
BackgroundSystemic sclerosis (SSc) is a connective tissue disease with ethnic differences. Single-nucleotide polymorphisms (SNPs) in theARID3A,CXCR5, andTNFSF8genes have been reported to be associated with various autoimmune diseases. The aim of this study was to investigate the association between these SNPs and susceptibility to SSc in a Chinese Han population.MethodsA case–control study was conducted in 342 patients with SSc and 694 ethnically matched healthy controls. SNPs inARID3A,CXCR5, andTNFSF8were genotyped using a Sequenom MassArray iPLEX system, and allele association analyses were performed using the PLINK v1.90 software.ResultsOur study demonstrated that theARID3Ars10415976 G andCXCR5rs77871618 T alleles were suggestively associated with patients with SSc (P= 0.049 andP= 0.024, respectively) andTNFSF8rs1555457 T allele was strongly associated with SSc (P= 0.003). Patients carrying theARID3Ars350146 TT andTNFSF8rs1555457 TT genotypes had a significant increased risk of SSc (P= 0.03 andP= 0.004, respectively). Moreover, rs10415976, rs77871618, and rs1555457 were associated with SSc in an additive genetic model (P< 0.05). rs62132345 and rs1555457 were associated with SSc in the dominant genetic model (P< 0.05). rs350146 was associated with SSc in the recessive genetic model (P= 0.029).ConclusionsARID3Ars10415976,ARID3Ars350146, andCXCR5rs77871618 were suggestively associated with SSc andTNFSF8rs1555457 was strongly associated with SSc in the Chinese Han population in this study.Key Points•This case-control study determined that ARID3A rs10415976, ARID3A rs350146 and CXCR5 rs77871618 were suggestively associated with SSc and TNFSF8 rs1555457 was strongly associated with SSc in the Chinese Han population.•The differences in these results compared with previous studies may be a result of ethnic and racial differences.
