Ethical consideration of incidental findings on adult brain MRI in research
Ethical consideration of incidental findings on adult brain MRI in research
复制标题
DOI：
10.1212/01.wnl.0000118531.90418.89
复制
发表时间：
2004-03-23
期刊：
影响因子：
9.9
通讯作者：
Atlas, SW
中科院分区：
文献类型：
--
作者：
Illes, J;Rosen, AC;Atlas, SW
目的：描述年轻和老年研究志愿者脑部 MRI 中偶然发现的频率和严重程度，并对检测此类发现所带来的伦理挑战进行评估。方法：作者回顾了 151 份研究 MRI 扫描，这些扫描是从作为健康志愿者招募参加研究的受试者中回顾性获得的。偶然发现分为四类：无转诊、常规、紧急或立即转诊。 p 显着性值是根据偶然事件的 chi(2) 检验计算得出的。结果：在 151 项研究中，作者发现需要转诊的偶然发现的总体发生率为 6.6%。按年龄划分，老年队列（年龄 >60 岁）比年轻队列有更多发现（p
Objective: To characterize the frequency and severity of incidental findings in brain MRIs of young and older adult research volunteers, and to provide an evaluation of the ethical challenges posed by the detection of such findings. Methods: The authors reviewed 151 research MRI scans obtained retrospectively from subjects recruited to studies as healthy volunteers. Incidental findings were classified into four categories: no referral, routine, urgent, or immediate referral. p Values for significance were computed from chi(2) tests of contingency. Results: Of 151 studies, the authors found an overall occurrence of incidental findings having required referral of 6.6%. By age, there were more findings in the older cohort (aged >60 years) than in the younger cohort (p