ACETOLACTATE SYNTHASE IS THE SITE OF ACTION OF 2 SULFONYLUREA HERBICIDES IN HIGHER-PLANTS
ACETOLACTATE SYNTHASE IS THE SITE OF ACTION OF 2 SULFONYLUREA HERBICIDES IN HIGHER-PLANTS
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DOI：
10.1126/science.224.4656.1443
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
MAUVAIS, CJ
中科院分区：
文献类型：
--
作者：
CHALEFF, RS;MAUVAIS, CJ
对除草剂氯磺隆和甲磺隆的烟草[Nicotiana tabacum]突变体的生化和遗传研究表明，这些磺酰脲类除草剂抑制乙酰乳酸合酶，这是支链氨基酸生物合成途径特有的第一种酶。该突变体的抗性是通过产生一种对两种除草剂的抑制不敏感的酶来实现的。
Biochemical and genetic studies of a tobacco [Nicotiana tabacum] mutant resistant to the herbicides chlorsulfuron and sulfometuron-methyl demonstrated that these sulfonylurea herbicides inhibit acetolactate synthase, the 1st enzyme specific to the branched chain amino acid biosynthetic pathway. Resistance of this mutant is accomplished by production of a form of the enzyme that is insensitive to inhibition by the 2 herbicides.