Effect of circulating fibronectin on stimulation of leukocyte oxygen consumption and serum opsonizing function in burned patients.
Effect of circulating fibronectin on stimulation of leukocyte oxygen consumption and serum opsonizing function in burned patients.
复制标题
循环纤连蛋白对烧伤患者白细胞耗氧量和血清调理功能刺激的影响。
DOI：
10.1097/00005373-198310000-00007
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Baxter,CR
中科院分区：
文献类型：
--
作者：
Dobke,MK;Pearson,G;Roberts,C;Germany,B;Heck,E;Masters,BS;Baxter,CR
In a study of 27 thermally burned patients (mean TBSA, 58%; range, 32-96%) serum fibronectin levels were decreased with parallel decreased oxygen consumption of stimulated peripheral blood phagocytes and decreased EGTA-blocked burn serum opsonizing activity which correlated with serum fibronectin changes postburn. Normal and burn sera fibronectin content also correlated with the opsonizing times for zymosan and Staphylococcus aureus but not for Enterobacteriaceae. Although in vivo 14 cases showed circulating fibronectin 140 [mu] g/ml or lower and a marked decrease in Staphylococcus aureus opsonization, only two patients from this group revealed positive Staphylococcus aureus blood cultures and serum fibronectin levels were higher in patients with Staphylococcus aureus sepsis than in patients with Enterobacteriaceae sepsis. Supplementary experiments on leukocyte oxidative response after zymosan stimulation in normal, fibronectin-depleted, and fibronectin-reconstituted serum demonstrated that the lag period of oxygen burst is a fibronectin-dependent reaction.
