Reconstituted bovine skin collagen enhances healing of bone wounds in the rat calvaria
Reconstituted bovine skin collagen enhances healing of bone wounds in the rat calvaria
复制标题
重组牛皮胶原蛋白可促进大鼠颅骨骨伤口的愈合
DOI：
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发表时间：
1988
影响因子：
4.2
通讯作者：
K. Parisien
中科院分区：
文献类型：
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作者：
D. Deporter;N. Komori;T. Howley;A. Shiga;Alan Ghent;P. Hansel;K. Parisien
摘要在直径为 4 毫米的手术造成的大鼠颅盖缺损中，测试了重建纤维状胶原蛋白（Zyderm 胶原蛋白植入物 I，胃蛋白酶溶解的牛皮肤胶原蛋白的浓缩溶液）作为骨移植材料的价值。所有伤口均允许愈合 4 周，并通过定性和计算机辅助形态测量进行评估。研究发现，与没有移植物或热变性的纤维状胶原相比，纤维状胶原产生的新骨明显更多。纤维状胶原蛋白通常具有良好的耐受性，似乎充当了良好的骨传导体，并融入了新形成的骨骼中。还通过比较 3.5% 的纤维状胶原蛋白（Zyderm 胶原蛋白植入物 I）与 6.5% 的胶原蛋白悬浮液（Zyderm 胶原蛋白植入物 II）来测试胶原蛋白浓度的影响。没有观察到显着差异，但 Zyderm II 明显的趋势是比 Zyderm I 促进更多的骨形成。结论是，重组纤维胶原是一种适宜的骨传导物质，可增强大鼠颅骨缺损的骨愈合。
SummaryThe value of reconstituted fibrillar collagen (Zyderm Collagen Implant I, a concentrated solution of pepsin-solubilized, bovin skin collagen) as a bone graft material was tested in 4 mm diameter surgically created defects of rat calvaria. All wounds were allowed to heal for 4 weeks, and were assessed both qualitatively and by computer-assisted morphometry. The fibrillar collagen was found to produce significantly more new bone than no graft or than heat-denatured fibrillar collagen. The fibrillar collagen was generally well tolerated, appeared to act as a hospitable osteoconductor, and became incorporated into the newly formed bone. The effect of collagen concentration was also tested by comparing the fibrillar collagen at 3.5% (Zyderm Collagen Implant I) with 6.5% suspension of collagen (Zyderm Collagen Implant II). There were no significant differences observed, but a definite trend was evident for Zyderm II to encourage more bone formation than Zyderm I. It is concluded that reconstituted fibrillar collagen is a hospitable, osteoconductive substance that enhances bone healing of calvarial defects in the rat.