Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)
Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)
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DOI：
10.1002/ijc.21678
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发表时间：
2006-05-15
影响因子：
6.4
通讯作者：
Riboli, E
中科院分区：
文献类型：
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作者：
González, CA;Pera, G;Riboli, E
人们认为水果和蔬菜(F&V)可以预防食道癌和胃癌。然而，最近的两项荟萃分析表明，与GC的关联强度在蔬菜中似乎比水果弱，在队列中比病例对照研究中弱。没有关于食管腺癌(ACO)的队列研究的证据。在10个欧洲国家的521,457名参与这一史诗队列的男性和女性中，饮食和生活方式的信息是在基线上收集的。经过平均6.5年的随访，共有330例GC和65例ACO被用于分析，这些病例经过一个病理学家小组的确认和分类。我们研究了F&V摄入量与GC和ACO的关系。在子样本中的校准研究被用来控制饮食测量误差。在病例的子样本和对照组的随机样本中，检测了幽门螺杆菌(HP)的抗体，并在嵌套式病例对照研究中检查了与F&V的相互作用。我们没有观察到总蔬菜摄入量或特定蔬菜组与胃癌风险之间的相关性，除了肠道类型，在肠道类型中，总蔬菜摄入量(校准后的HR 0.66；95%CI为0.35-1.22/100克)和洋葱和大蒜的摄入量(校准后HR为0.70；95%CI为0.38-1.29/10克)可能存在负相关。没有观察到新鲜水果摄入量与GC风险之间存在关联的证据。我们发现，柑橘类水果的摄入量与心脏部位呈负相关，但不显著(校正后的HR为0.77；95%可信区间为0.47-1.22/100g)，而与非心脏部位无关联。至于ACO，我们发现蔬菜摄入量和柑橘摄入量没有显著的负相关(校正后的HRS0.72；95%CI分别为0.32-1.64和0.77；95%CI为0.46-1.28每100克和50克增加)。似乎嘴唇感染并不会改变F&V摄入量的效果。我们的研究支持蔬菜摄入在肠型GC和ACO中可能的保护作用。食用柑橘类水果可能在预防心绞痛、GC和ACO方面起到一定作用。(C)2005年Wiley-Liss，Inc.
It is considered that fruit and vegetable (F&V) protect against oesophagus and gastric cancer (GC). However, 2 recent meta-analyses suggest that the strength of association on GC seems to he weaker for vegetables than for fruit and weaker in cohort than in case-control studies. No evidence exists from cohort studies about adenocarcinoma of oesophagus (ACO). In 521,457 men and women participating in the EPIC cohort in 10 European countries, information of diet and lifestyle was collected at baseline. After an average of 6.5 years of follow-up, a total of 330 GC and 65 ACO, confirmed and classified by a panel of pathologists, was used for the analysis. We examined the relation between F&V intake and GC and ACO. A calibration study in a sub-sample was used to control diet measurement errors. In a sub-sample of cases and a random sample of controls, antibodies against Helicobacter pylori (Hp) were measured and interactions with F&V were examined in a nested case-control study. We observed no association with total vegetable intake or specific groups of vegetables and GC risk, except for the intestinal type, where a negative association is possible regarding total vegetable (calibrated HR 0.66; 95% CI 0.35-1.22 per 100 g increase) and onion and garlic intake (calibrated HR 0.70; 95% CI 0.38-1.29 per 10 g increase). No evidence of association between fresh fruit intake and GC risk was observed. We found a negative but non significant association between citrus fruit intake and the cardia site (calibrated HR 0.77; 95% CI 0.47-1.22 per 100 g increase) while no association was observed with the non-cardia site. Regarding ACO, we found a non significant negative association for vegetable intake and for citrus intake (calibrated HRs 0.72; 95% Cl 0.32-1.64 and 0.77; 95% CI 0.46-1.28 per 100 and 50 g increase, respectively). It seems that lip infection does not modify the effect of F&V intake. Our study supports a possible protective role of vegetable intake in the intestinal type of GC and the ACO. Citrus fruit consumption may have a role in the protection against cardia GC and ACO. (c) 2005 Wiley-Liss, Inc.