Circulating anti-C3b IgG in lupus nephritis: A large cohort study
Circulating anti-C3b IgG in lupus nephritis: A large cohort study
复制标题
狼疮性肾炎中的循环抗 C3b IgG：一项大型队列研究
DOI：
10.1016/j.clim.2020.108514
复制
发表时间：
2020
影响因子：
8.6
通讯作者：
Zhao Ming-Hui
中科院分区：
文献类型：
--
作者：
Tao Juan;Song Di;Liu Xiao-Ling;Yu Feng;Zhao Ming-Hui
本研究旨在分析抗C3 b IgG的临床意义和生物功能特性的基础上，狼疮性肾炎队列。我们发现，在我们的队列中，抗C3 b IgG的患病率为47.8%。抗-C3 b IgG阳性患者的SLEDAI显著升高，循环C3和C4水平显著降低。抗C3 b IgG水平与肾脏和几个活动性病变中的C3或C1 q沉积呈正相关。抗C3 b IgG阳性是增殖性狼疮肾炎患者亚组复合终点的独立危险因素。在体外，从阳性患者纯化的IgG组分导致通过旁路途径增加C3 a的产生，并干扰因子H和CR 1与C3 b的结合。提示抗C3 b IgG与狼疮性肾炎患者局部肾损伤及远期预后相关，可能通过导致补体旁路途径过度激活而实现。
The current study aimed to analyze the clinical significance and bio-functional properties of anti-C3b IgG based on a lupus nephritis cohort. We found that the prevalence of anti-C3b IgG in our cohort was 47.8%. Patients with positive anti-C3b IgG had significantly higher SLEDAI, lower circulating C3 and C4 levels. Anti-C3b IgG levels were positively correlated with C3 or C1q deposition in kidneys and several active pathological lesions. The positivity of anti-C3b IgG was an independent risk factor for the composite endpoints in the subgroup of proliferative lupus nephritis patients. In vitro, the purified IgG fractions from positive patients resulted in increased C3a generation through the alternative pathway, and interfered factor H and CR1 binding to C3b. Our findings indicated that anti-C3b IgG associated with local renal injury and long-term outcomes in lupus nephritis patients, possibly through leading to the complement alternative pathway over-activation.