A short synthesis of 5-methoxy-2,2-dimethyl-2H-1-benzopyran-6-propanoic acid methyl ester
A short synthesis of 5-methoxy-2,2-dimethyl-2H-1-benzopyran-6-propanoic acid methyl ester
复制标题
DOI：
10.1016/s0040-4020(01)00456-2
复制
发表时间：
2001-06-18
期刊：
影响因子：
2.1
通讯作者：
Jacobs, H
中科院分区：
文献类型：
--
作者：
Henry, GE;Jacobs, H
以2,4-二羟基苯甲醛为原料，经5步合成5-甲氧基-2,2-二甲基- 2h -1-苯并吡喃-6-丙酸甲酯，总收率约为20%。两个关键反应是松苯甲醛的未螯合羟基与C-3之间的铬酰化反应和丙二酸二甲酯与碘化季铵的脱甲氧羰基烷基化反应。2001爱思唯尔科学有限公司版权所有。
5-Methoxy-2,2-dimethyl-2H-1-benzopyran-6-propanoic acid methyl ester was prepared in five steps and approximately 20% overall yield from 2,4-dihydroxybenzaldehyde. The two key reactions are the chromenylation between the unchelated hydroxyl group and C-3 of the resbenzaldehyde and the demethoxycarbonylation-alkylation of dimethyl malonate with a quaternary ammonium iodide. (C) 2001 Elsevier Science Ltd. All rights reserved.