ASSOCIATION BETWEEN CARDIAC SURGERY AND MORTALITY AMONG PATIENTS WITH INFECTIVE ENDOCARDITIS COMPLICATED BY SEPSIS AND SEPTIC SHOCK
ASSOCIATION BETWEEN CARDIAC SURGERY AND MORTALITY AMONG PATIENTS WITH INFECTIVE ENDOCARDITIS COMPLICATED BY SEPSIS AND SEPTIC SHOCK
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DOI：
10.1097/shk.0000000000001013
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发表时间：
2018-05-01
期刊：
影响因子：
3.1
通讯作者：
Barsic, Bruno
中科院分区：
文献类型：
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作者：
Krajinovic, Vladimir;Ivancic, Stipe;Barsic, Bruno
背景：脓毒症和脓毒性休克是感染性心内膜炎（IE）的常见表现，但对这组患者的临床特征、手术治疗的使用及其与预后的关系知之甚少。我们试图确定心脏手术（CS）对脓毒症严重程度不同阶段IE患者预后的影响。方法：2000 ~ 2011年住院的确诊IE患者294例，均为天然或人工瓣膜IE。前瞻性评价：采用多变量logistic回归评估按脓毒症严重程度分层的手术和药物治疗患者的临床特征和结局（住院和1年死亡率），并采用新的脓毒症-3定义。结果：IE期间脓毒症或脓毒性休克的存在与住院死亡率增加有统计学关系(优势比[or] 8.915， P
Background: Sepsis and septic shock are common presentations of infective endocarditis (IE), but little is known about clinical characteristics in this group of patients, use of surgical treatment, and their associations with outcome. We sought to determine the influence of cardiac surgery (CS) on the outcome of patients with IE in different stages of sepsis severity. Methods: Two hundred ninety four patients with definite IE native or prosthetic valve IE admitted between 2000 and 2011. Prospective evaluation using multivariable logistic regression to evaluate clinical characteristics and outcomes (in-hospital and 1-year mortality) in surgically and medically treated patients stratified by severity of sepsis and using new Sepsis-3 definitions. Results: The presence of sepsis or septic shock during IE showed a statistical relationship with increased in-hospital mortality (odds ratio [OR] 8.915, P