Cytotoxicity and Antibacterial Potential of Halogenated Chamigrenes from Malaysian Red Alga, Laurencia majuscula
Cytotoxicity and Antibacterial Potential of Halogenated Chamigrenes from Malaysian Red Alga, Laurencia majuscula
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来自马来西亚红藻 Laurencia majuscula 的卤化 Chamigrenes 的细胞毒性和抗菌潜力
DOI：
10.1055/a-0977-4418
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Vairappan Charles Santhanaraju
中科院分区：
文献类型：
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作者：
Kamada Takashi;Phan Chin-Soon;Okino Tatsufumi;Vairappan Charles Santhanaraju
已知劳伦西亚属的红藻能产生广泛的生物活性次生代谢产物。本文报道了从北婆罗洲曼塔尼岛(Laurencia Majuscula(Harvey)Lucas)的种群中分离得到的两个新的卤代香芹酮A(1)和B(2)，以及7个已知化合物：树状二醇(3)、(+)-香豆醇(4)、软骨醇(5)、牛油醇(6)、(+)-月桂烯酮B(7)、2-氯-3-羟基-α-香豆酮-9-酮(8)和葛根醇A(9)。根据波谱数据(IR、1D和2D核磁共振、MS)确定了两个新代谢物的结构。从该藻类中分离得到的化合物具有较强的细胞毒性(HeLa、MCF-7、P-388)和抗菌(对临床耐药细菌)活性。该种群的主要代谢物在全球该物种的地理分布中具有重要意义。
Red algae of the genusLaurenciahave been known to produce a wide array of bioactive secondary metabolites. Here, we report the isolation of two new halogenated chamigrenes, lauremantanones A (1) and B (2), along with seven known compounds, dendroidiol (3), (+)-elatol (4), cartilagineol (5), obtusol (6), (+)-laurencenone B (7), 2-chloro-3-hydroxy-α-chamigren-9-one (8), and puertitol A (9), from a population ofLaurencia majuscula(Harvey) Lucas from Mantanani Island (North Borneo). The structures of the two new metabolites were determined based on spectroscopic data (IR, 1D and 2D NMR, and MS). Compounds isolated from this alga exhibited potent cytotoxic (HeLa, MCF-7, P-388) and antibacterial (against antibiotic-resistant clinical bacteria) activities. The major metabolite of this population has significant importance in the geographical distribution of this species globally.