Potential of LH Receptor as an Immunocontraceptive Vaccine: Studies in the Baboon (Papio)

Potential of LH Receptor as an Immunocontraceptive Vaccine: Studies in the Baboon (Papio)
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LH 受体作为免疫避孕疫苗的潜力:对狒狒 (Papio) 的研究

DOI:
10.1007/978-1-4612-3746-4_22
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发表时间:
1988
期刊:
影响因子:
6.1
通讯作者:
Mukul Singh
Mukul Singh
中科院分区:
医学2区
文献类型:
--
作者:
B. Saxena;Mukul Singh

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在新的方法中,生育的免疫调节最近受到了相当大的关注(7,14,15)。针对卵子、精子和胎盘中存在的抗原(1),特别是绒毛膜促性腺激素β亚单位的免疫接种,证明了免疫避孕疫苗的潜力(15)。如图22.1所示,我们研究了针对促黄体生成素受体(12)的主动免疫对雌性狒狒(Papio)卵巢功能的影响。我们的观察表明,黄体生成素受体具有开发避孕疫苗的潜力(13)。
Among the new approaches, the immunological regulation of fertility has recently received considerable attention (7,14,15). Immunization against antigens present in the ovum, sperm, and placenta (1), especially the β-subunit of the chorionic gonadotropin, has demonstrated a potential of an immunocontraceptive vaccine (15). We have examined the concept of active immunization against lutenizing hormone (LH) receptor (12) on the ovarian function of female baboons (Papio), as shown in Figure 22.1. Our observations have indicated that LH receptor has a potential for the development of a contraceptive vaccine (13).
人黄体促性腺激素刺激的腺苷酸环化酶的特性:鸟苷酸和镁离子调节激素反应性。
DOI: 10.1210/jcem-59-2-219
发表时间: 1984
期刊: The Journal of clinical endocrinology and metabolism
影响因子: --
作者:
Rojas,FJ;Asch,RH
通讯作者: Asch,RH