Gastrointestinal colonization by methicillin-resistant Staphylococcus aureus in immunosuppressed mice
Gastrointestinal colonization by methicillin-resistant Staphylococcus aureus in immunosuppressed mice
复制标题
耐甲氧西林金黄色葡萄球菌在免疫抑制小鼠胃肠道定植
DOI：
10.1128/iai.64.10.4231-4235.1996
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发表时间：
1996
影响因子：
3.1
通讯作者：
K. Okonogi
中科院分区：
文献类型：
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作者：
Naoko KATO;K. Okonogi
ICR小鼠鼻内接种耐甲氧西林金黄色葡萄球菌（MRSA）N133，并从盲肠和粪便中定量回收接种的MRSA。从盲肠中回收的MRSA活菌计数与粪便中的MRSA活菌计数相关性良好。一些小鼠在接种后14天从盲肠消除MRSA。在接种前3天以200 mg/kg的剂量腹膜内给予环磷酰胺抑制了MRSA从盲肠和粪便中的消除。所有环磷酰胺处理的小鼠排泄超过10（4）CFU/g粪便的MRSA至少70天，表明MRSA在胃肠道中的持续定植。一些β-内酰胺类抗生素降低了定植水平，但其他抗生素则没有。建议定植水平取决于抗生素对MRSA的抗菌活性和抗生素对肠道植物群的干扰程度。
ICR mice were inoculated intranasally with methicillin-resistant Staphylococcus aureus (MRSA) N133, and the inoculated MRSA was quantitatively recovered from the ceca and feces. The viable counts of the MRSA recovered from ceca correlated well with those from feces. Some mice eliminated MRSA from the cecum by 14 days after inoculation. Intraperitoneal administration of cyclophosphamide at a dose of 200 mg/kg 3 days before inoculation inhibited the elimination of the MRSA from both ceca and feces. All mice treated with cyclophosphamide excreted more than 10(4) CFU of the MRSA per g of feces for at least 70 days, indicating persistent colonization of the MRSA in the gastrointestinal tract. Some beta-lactam antibiotics decreased the colonization level, but others did not. The colonization level was suggested to depend on the antibacterial activity of the antibiotic against the MRSA and the degree of disturbance of intestinal flora by the antibiotic.
无菌 SCID 小鼠的粘膜和播散性念珠菌病。
DOI：
10.1080/02681219380000161
发表时间：
1993
期刊：
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology
影响因子：
--
作者：
Balish,E;Jensen,J;Warner,T;Brekke,J;Leonard,B
通讯作者：
Leonard,B