Nucleolar organizer regions in spitz nevi and malignant melanomas
Nucleolar organizer regions in spitz nevi and malignant melanomas
复制标题
斯皮茨痣和恶性黑色素瘤的核仁组织区
作者：
A. Howat;D. Giri;D. Cotton;D. Slater
核仁组织区 (NOR) 是转录核糖体 RNA 的 DNA 环；使用银 (Ag) 方法可以在福尔马林固定石蜡包埋的组织中轻松识别它们。有人提出，每个细胞的 AgNOR 数量可以区分皮肤的良性和恶性黑素细胞病变。我们通过相同的银法研究了 29 例斯皮茨痣 (SN) 和 39 例侵袭性恶性黑色素瘤 (MM)。 SN 显示每个细胞 1.0 至 1.6 AgNOR，平均值为 1.2。 MM 计数范围为 1.2 至 4.2，平均值为 2.0。结论是AgNOR方法不能可靠地区分SN和MM；然而，如果每个细胞的 AgNOR 计数超过 2.0 个，则有利于诊断 MM 而不是 SN。
Nucleolar organizer regions (NOR) are loops of DNA that transcribe ribosomal RNA; they can be easily identified in formalin fixed paraffin embedded tissue using a silver (Ag) method. It has been suggested that the number of AgNOR per cell can differentiate between benign and malignant melanocytic lesions of skin. We have studied 29 Spitz nevi (SN) and 39 invasive malignant melanomas (MM) by the same silver method. SN showed between 1.0 and 1.6 AgNOR per cell with a mean of 1.2. MM counts ranged from 1.2 to 4.2 with a mean of 2.0. It is concluded that the AgNOR method cannot reliably differentiate SN from MM; however, a count of more than 2.0 AgNOR per cell would favor a diagnosis of MM rather than SN.