One-Pot Synthesis of Symmetrical and Asymmetrical 3-Amino Diynes via Cu(I)-Catalyzed Reaction of Enaminones with Terminal Alkynes
One-Pot Synthesis of Symmetrical and Asymmetrical 3-Amino Diynes via Cu(I)-Catalyzed Reaction of Enaminones with Terminal Alkynes
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Cu(I)催化烯胺酮与末端炔烃反应一锅法合成对称和不对称3-氨基二炔
DOI：
10.1021/acs.orglett.1c02848
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发表时间：
2021
期刊：
影响因子：
5.2
通讯作者：
Zeng Li
中科院分区：
文献类型：
--
作者：
Changyuan Zhang;Huosheng Guo;Lulu Chen;Jiantao Zhang;Mengping Guo;Xuncheng Zhu;Chan Shen;Zeng Li
描述了一种通过烯胺酮和末端炔烃的 Cu(I) 催化反应直接构建氨基跳跃二炔的经济且有效的方案。在温和的条件下，通过一锅反应可以得到不同种类的对称和不对称的3-氨基二炔，收率高达83%。
An economical and efficient protocol for the direct construction of amino skipped diynes through the Cu(I)-catalyzed reaction of enaminones and terminal alkynes has been described. Different kinds of symmetrical and asymmetrical 3-amino diynes could be obtained in up to 83% yield through a one-pot reaction under mild conditions.