Aquaporins in Obesity
Aquaporins in Obesity
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DOI：
10.1007/978-94-024-1057-0_15
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发表时间：
2017-01-01
期刊：
影响因子：
--
通讯作者：
Soveral, Graca
中科院分区：
文献类型：
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作者：
da Silva, Ines Vieira;Soveral, Graca
肥胖是本世纪最重要的代谢紊乱之一，并且与一组最危险的心血管疾病危险因素相关，如胰岛素抵抗和糖尿病、血脂异常和高血压，统称为代谢综合征。水通道蛋白在甘油代谢中的作用是促进甘油从脂肪组织释放并分布到各种组织和器官，揭示了这些膜通道在脂质平衡和能量稳态中的重要作用，并指出它们参与了多种病理生理机制，包括胰岛素抵抗、肥胖和糖尿病。描述了它们的特定组织分布、它们参与甘油平衡以及它们在肥胖和脂肪相关代谢并发症中的意义。开发能够调节脂肪组织中水甘油通道蛋白（特别是AQP7）表达和功能的特定药理学调节剂可能构成控制肥胖和其他代谢紊乱的新方法。
Obesity is one of the most important metabolic disorders of this century and is associated with a cluster of the most dangerous cardiovascular disease risk factors, such as insulin resistance and diabetes, dyslipidemia and hypertension, collectively named Metabolic Syndrome. The role of aquaporins in glycerol metabolism facilitating glycerol release from the adipose tissue and distribution to various tissues and organs, unveils these membrane channels as important players in lipid balance and energy homeostasis and points to their involvement in a variety of pathophysiological mechanisms including insulin resistance, obesity and diabetes.This review summarizes the physiologic role of aquaglyceroporins in glycerol metabolism and lipid homeostasis, describing their specific tissue distribution, their involvement in glycerol balance and their implication in obesity and fat-related metabolic complications. The development of specify pharmacologic modulators able to regulate aquaglyceroporins expression and function, in particular AQP7 in adipose tissue, might constitute a novel approach for controlling obesity and other metabolic disorders.