Five-year surveillance of acute flaccid paralysis in Malaysia
Five-year surveillance of acute flaccid paralysis in Malaysia
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DOI：
10.1111/j.1440-1754.2004.00312.x
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发表时间：
2004-03-01
影响因子：
1.7
通讯作者：
Taha, AM
中科院分区：
文献类型：
--
作者：
Hussain, IHMI;Ali, S;Taha, AM
目的：马来西亚于1995年实施了全国范围的急性弛缓性麻痹监测，并于1996年进一步加强，作为世界卫生组织（卫生组织）在西太平洋区域消除小儿麻痹症认证过程的一部分。对1997年至2001年5年监测期间AFP病例的临床资料进行了整理和分析。结果：5年期间报告AFP病例517例，15岁以下儿童AFP总发病率为1.2/10万。与AFP相关的主要临床诊断为格林-巴利综合征（30.2%）、中枢神经系统感染（16.2%）、横肌麻痹（10.6%）、非脊髓灰质炎肠道病毒感染（6.2%）和低钾性麻痹（5.2%）。这种中枢神经系统感染和非脊髓灰质炎肠道病毒感染过量的不寻常模式归因于1997年肠道病毒71型感染在全国范围内的爆发。根据世卫组织病毒学分类，没有因野生脊髓灰质炎病毒而导致的脊髓灰质炎病例。三例是“脊髓灰质炎兼容”，没有疫苗相关的麻痹性脊髓灰质炎（VAPP）的情况下，而62例（12.0%）仅被归类为“非脊髓灰质炎AFP”。结论：总体而言，这些数据表明，没有野生脊髓灰质炎病毒在马来西亚的流通，从1997年至2001年。本研究中AFP的模式与其他已发表的报告不同。
Objective: The nation-wide surveillance for acute flaccid paralysis (AFP) was implemented in Malaysia in 1995 and further intensified in 1996 as part of the World Health Organization's (WHO) certification process for polio eradication in the Western Pacific Region. Clinical data on AFP cases during a 5-year surveillance period from 1997 to 2001 were compiled and analysed.Results: Based on 517 cases of AFP reported during this 5-year period, the overall rate of AFP was 1.2 per 100 000 children below 15 years old. The major clinical diagnosis associated with AFP were Guillain-Barre syndrome (30.2%), central nervous system infection (16.2%), transverse myelitis (10.6%) non-polio enterovirus infection (6.2%), and hypokalaemic paralysis (5.2%). This unusual pattern with an excess of CNS infection and non-polio enterovirus infection was attributed to the outbreak of enterovirus 71 infection nation-wide in 1997. According to the WHO virological classification, there was no case of poliomyelitis due to wild poliovirus. Three cases were 'polio compatible', there were no cases of vaccine-associated paralytic polio (VAPP), while 62 cases (12.0%) were merely classified as 'non-polio AFP'.Conclusion: Overall, these data suggest the absence of circulation of wild poliovirus in Malaysia from 1997 to 2001. The pattern of AFP in this study is different from other published reports.