Optic Disc Perfusion in Primary Open Angle and Normal Tension Glaucoma Eyes Using Optical Coherence Tomography-Based Microangiography.
Optic Disc Perfusion in Primary Open Angle and Normal Tension Glaucoma Eyes Using Optical Coherence Tomography-Based Microangiography.
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DOI：
10.1371/journal.pone.0154691
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Chen PP
中科院分区：
文献类型：
--
作者：
Bojikian KD;Chen CL;Wen JC;Zhang Q;Xin C;Gupta D;Mudumbai RC;Johnstone MA;Wang RK;Chen PP
采用基于光学相干断层扫描（OCT）的光学微血管造影（OMAG）技术研究正常、原发性开角型青光眼（POAG）和正常眼压性青光眼（NTG）眼的视盘灌注差异。横断面观察性研究。28名正常人、30名POAG和31名NTG受试者。使用以视神经乳头（ONH）为中心的基于68 kHz Cirrus HD-OCT 5，000的OMAG原型系统（Carl Zeiss Meditec Inc，都柏林，CA）扫描每名受试者的一只眼睛。通过检测连续B扫描之间OCT信号的差异，从OMAG数据集生成微血管图像。通过半自动分割程序分离前层（preLC）。视盘灌注，量化为ONH内的流量、血管面积密度和标准化流量（通过血管面积标准化的流量）。与正常眼相比，青光眼眼在preLC中的所有三个灌注度量中具有显著较低的视盘灌注（p<0.0001）。POAG和NTG组的视野（VF）平均差（MD）和图形标准差（PSD）相似，POAG和NTG组的视盘灌注无差异。单因素分析显示，POAG和NTG组的视盘灌注与VF MD、VF PSD和边缘面积均显著相关（p≤0.0288）。然而，仅在POAG眼中，正常化的视盘灌注与一些结构测量值（视网膜神经纤维层厚度和ONH杯/盘比）相关。与正常对照组相比，OMAG检测的POAG和NTG组的视盘灌注显著减少，但POAG和NTG组之间没有差异，VF损伤水平相似。椎间盘血流灌注与VF MD、VF PSD和边缘面积显著相关。使用OMAG测量的视盘血管变化可为青光眼的诊断和监测提供有用的信息。
To investigate optic disc perfusion differences in normal, primary open-angle glaucoma (POAG), and normal tension glaucoma (NTG) eyes using optical microangiography (OMAG) based optical coherence tomography (OCT) angiography technique. Cross-sectional, observational study. Twenty-eight normal, 30 POAG, and 31 NTG subjects. One eye from each subject was scanned with a 68 kHz Cirrus HD-OCT 5,000-based OMAG prototype system centered at the optic nerve head (ONH) (Carl Zeiss Meditec Inc, Dublin, CA). Microvascular images were generated from the OMAG dataset by detecting the differences in OCT signal between consecutive B-scans. The pre-laminar layer (preLC) was isolated by a semi-automatic segmentation program. Optic disc perfusion, quantified as flux, vessel area density, and normalized flux (flux normalized by the vessel area) within the ONH. Glaucomatous eyes had significantly lower optic disc perfusion in preLC in all three perfusion metrics (p<0.0001) compared to normal eyes. The visual field (VF) mean deviation (MD) and pattern standard deviation (PSD) were similar between the POAG and NTG groups, and no differences in optic disc perfusion were observed between POAG and NTG. Univariate analysis revealed significant correlation between optic disc perfusion and VF MD, VF PSD, and rim area in both POAG and NTG groups (p≤0.0288). However, normalized optic disc perfusion was correlated with some structural measures (retinal nerve fiber layer thickness and ONH cup/disc ratio) only in POAG eyes. Optic disc perfusion detected with OMAG was significantly reduced in POAG and NTG groups compared to normal controls, but no difference was seen between POAG and NTG groups with similar levels of VF damage. Disc perfusion was significantly correlated with VF MD, VF PSD, and rim area in glaucomatous eyes. Vascular changes at the optic disc as measured using OMAG may provide useful information for diagnosis and monitoring of glaucoma.