A comparative study of acquisition schemes for diffusion tensor imaging using MRI
A comparative study of acquisition schemes for diffusion tensor imaging using MRI
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DOI：
10.1006/jmre.1998.1673
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发表时间：
1999-03-01
影响因子：
2.2
通讯作者：
Carpenter, TA
中科院分区：
文献类型：
--
作者：
Papadakis, NG;Xing, D;Carpenter, TA
本研究探讨了扩散加权（DW）梯度方向的选择对扩散张量成像（DTI）实验精度的影响。理论分析提供了一个定量的框架，在其中的DTI方案的噪声性能可以客观地评估和开发新的DTI计划，它采用多个DW梯度方向。这个通用的框架首先应用于检查两个常用的DTI计划，其中采用6 DW梯度方向，迄今被不加区别地使用的唯一条件下的非共线性。然后，它被用来设计和评估一种新的12-DW梯度方向DTI协议，该协议采用与两种传统方案相同的DW采集总数（12）。然后，使用严格的模拟和对各向同性体模和健康人脑的DTI实验来证实该理论研究。理论和实验分析表明，这两个传统的计划表现出显着不同的噪声性能和使用新的多DW梯度方向计划明显提高了精度的DTI测量。(C)北京：科学出版社.
This study has investigated the effects of the selection of the diffusion-weighted (DW) gradient directions on the precision of a diffusion tensor imaging (DTI) experiment. The theoretical analysis provided a quantitative framework in which the noise performance of DTI schemes could be assessed objectively and for the development of novel DTI schemes, which employ multiple DW gradient directions. This generic framework was first applied to the examination of two commonly used DTI schemes, which employed 6 DW gradient directions and hitherto were used indiscriminately under the sole condition of noncollinearity. It was then used to design and assess a novel 12-DW-gradient-direction DTI protocol, which employed the same total number of DW acquisitions as the two conventional schemes (12), This theoretical investigation was then corroborated using rigorous simulation and DTI experiments on both an isotropic phantom and a healthy human brain. Both the theoretical and the experimental analysis demonstrated that the two conventional schemes showed a significantly different noise performance and that use of the new multiple-DW-gradient-direction scheme clearly improved the precision of the DTI measurements. (C) 1999 Academic Press.