Seeing a Tree Within the Forest: Selective Detection and Function of Somatodendritic Cholecystokinin Release From Dopamine Neurons in the Ventral Tegmental Area.
Seeing a Tree Within the Forest: Selective Detection and Function of Somatodendritic Cholecystokinin Release From Dopamine Neurons in the Ventral Tegmental Area.
复制标题
看到森林里的一棵树：腹侧被盖区多巴胺神经元释放的体树突胆囊收缩素的选择性检测和功能。
DOI：
10.1016/j.biopsych.2022.11.001
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发表时间：
2023
影响因子：
10.6
通讯作者：
Rice,MargaretE
中科院分区：
文献类型：
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作者：
Rice,MargaretE
体树突递质释放是指神经活性物质从细胞体（体细胞）和神经元树突的释放。关于体树突释放的最初报道是开创性的（1,2），考虑到递质释放是轴突公认的功能，结果出乎意料。事实上，传统教科书上的神经元图像显示，一端是细胞体和接受突触输入的树突，另一端是长轴突，轴突末端含有囊泡，另一端是释放的递质扩散云（图1A）。在这种情况下很少提到体树突递质释放（图1B）。因此，这个概念仍然会引起惊讶，即使是在成熟的神经科学家中。
Somatodendritic transmitter release refers to the release of a neuroactive substance from the cell body (soma) and dendrites of a neuron. Initial reports of somatodendritic release were pioneering (1, 2) and the results unexpected given that transmitter release is a well-recognized function of axons. Indeed, the conventional textbook image of a neuron shows a cell body and dendrites that receive synaptic input on one end and a long axon with a vesicle-containing terminals and diffusing clouds of released transmitter on the other end (Figure 1A). Somatodendritic transmitter release (Figure 1B) is rarely mentioned in this context. Consequently, the concept can still evoke surprise, even among established neuroscientists.