The impact of body mass index on assisted reproduction
The impact of body mass index on assisted reproduction
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DOI：
10.1097/gco.0b013e32832aee96
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发表时间：
2009-06-01
影响因子：
2.1
通讯作者：
Senturk, Levent Mehmet
中科院分区：
文献类型：
--
作者：
Erel, Cemal Tamer;Senturk, Levent Mehmet
综述目的肥胖是一个世界性的问题。肥胖对辅助生殖技术结局的影响存在很大争议，最近的研究发现，虽然没有绝对的共识，但肥胖可能会延长诱导排卵的时间，增加促性腺激素的剂量，降低峰值雌二醇水平，成熟卵泡数和获卵数，并增加周期取消率。此外，肥胖可能对卵母细胞和胚胎质量产生负面影响。因此，在许多研究中，受精、胚胎移植、植入和妊娠率通常很低。此外，由于肥胖本身，取卵和胚胎移植程序可能很困难。最后，发现流产率很高。目前，还没有一项与肥胖和辅助生殖相关的研究被设计为随机对照试验。肥胖的定义，不孕的原因，用于诱导排卵的方案，促性腺激素的起始剂量，卵母细胞和胚胎分级系统在研究中没有标准化。一些混杂因素，如多囊卵巢综合征的状态和年龄，没有考虑到.SummaryObesity对辅助生殖技术的结果有负面影响。
Purpose of reviewObesity is a worldwide problem. The effect of obesity on the outcome of assisted reproductive techniques is quite controversial.Recent findingsAlthough there is not an absolute consensus based on evidence, obesity may lengthen the duration of ovulation induction, increase the gonadotrophin dose, decrease the peak estradiol levels, number of mature follicles and number of oocytes retrieved, and increase the cycle cancellation rate. Moreover, obesity may have a negative impact on oocyte and embryo quality. Thus, fertilization, embryo transfer, implantation and pregnancy rates have been usually found to be low in many studies. In addition, oocyte retrieval and embryo transfer procedures can be difficult due to obesity itself. Finally, miscarriage rate is found to be high. None of the studies related with obesity and assisted reproduction has been designed as a randomized controlled trial, yet. Definition of obesity, cause of infertility, protocols used for ovulation induction, starting dose for gonadotrophins, oocyte and embryo-grading systems are not standardized among the studies. Some confounding factors, such as polycystic ovary syndrome status and age, are not taken into consideration.SummaryObesity has a negative impact on the outcomes of assisted reproductive techniques.