Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in rats
Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in rats
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DOI：
10.1016/s0091-3057(02)00715-3
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发表时间：
2002-06-01
影响因子：
3.6
通讯作者：
Crews, FT
中科院分区：
文献类型：
--
作者：
Obernier, JA;White, AM;Crews, FT
学习和记忆障碍是慢性酒精滥用的常见神经心理后遗症。酗酒者通常有顺行性记忆障碍，包括空间记忆功能障碍和反应持续的倾向。本研究旨在评估酗酒暴露对神经退行性变和认知功能的影响。大鼠每天给予乙醇三次，持续4天。银染显示嗅球、梨状皮质、嗅周皮质、内嗅皮质和齿状回的神经变性。停药后，Morris水迷宫中的行为测试显示治疗组之间的逆转学习存在显著差异。乙醇处理的动物需要更多的试验来学习逆转任务，更频繁地进入先前训练过的象限，并在那里花费更多的时间。[H-3]PK-11195结合（CNS损伤的指标）在乙醇处理动物的梨状皮质中升高。因此，酗酒乙醇暴露导致神经退行性病变的皮质边缘回路与共同的兴奋性输入从嗅球和与空间学习任务的持续反应。这些研究表明，一次酗酒事件可能导致人类神经退行性变和认知功能障碍。行为缺陷的持续性可能与认知功能障碍和成瘾过程的行为成分有关。(C)2002年爱思唯尔科技有限公司All rights reserved.
Impairments of learning and memory are common neuropsychological sequelae of chronic alcohol abuse. Alcoholics often have impairments of anterograde memory, including spatial memory dysfunction, and a tendency toward response perseveration. This study was designed to assess the effects of binge ethanol exposure on neurodegeneration and cognitive function. Rats were given ethanol three times daily for 4 days. Silver staining revealed neurodegeneration in the olfactory bulb, piriform cortex, perirhinal cortex, entorhinal cortex, and dentate gyrus. After withdrawal, behavioral testing in the Morris water maze revealed significant differences in reversal learning between treatment groups. Ethanol-treated animals required more trials to learn the reversal task, entered the previously trained quadrant more often, and spent more time there than controls. [H-3]PK-11195 binding, an index of CNS damage, was elevated in the piriform cortex of ethanol-treated animals. Thus, binge ethanol exposure resulted in neurodegeneration of a corticolimbic circuit with common excitatory inputs from the olfactory bulb and was associated with perseverative responding on a spatial learning task. These studies suggest that a single binge drinking episode could cause neuro degeneration and cognitive dysfunction in humans. The perseverative nature of the behavioral deficit could be related to both cognitive dysfunction and the behavioral components of the addiction process. (C) 2002 Elsevier Science Inc. All rights reserved.