Preventive effect of fermented brown rice and rice bran on spontaneous type 1 diabetes in NOD female mice
Preventive effect of fermented brown rice and rice bran on spontaneous type 1 diabetes in NOD female mice
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DOI：
10.1016/j.jff.2021.104356
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发表时间：
2021-03
影响因子：
5.6
通讯作者：
K. Kataoka;H. Nemoto;Akiko Sakurai;K. Yasutomo;Masataka Shikanai
中科院分区：
文献类型：
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作者：
K. Kataoka;H. Nemoto;Akiko Sakurai;K. Yasutomo;Masataka Shikanai
食用糙米和米糠发酵曲霉菌（FBRA）抑制自发发生糖尿病的雌性NOD小鼠。对照饮食喂养的小鼠在20周龄左右显示糖尿和高血糖，并且在30周龄时该比率达到57%，而在含0.5%FBS的饮食喂养的组中该比率没有增加。与对照组相比，30周龄的FBRA喂养组保持了较高的完整胰岛比例，并显示出显著较低的胰岛炎评分，FBRA的剂量依赖性从0.25%至0.5%的膳食浓度。与对照组相比，24周龄时糖尿病小鼠的百分比显著较低（p = 0.01，对数秩检验）。这些结果表明，饮食中给予0.5%FBRA延迟NOD小鼠糖尿病自发发作的抑制作用可能是通过维持完整胰岛的数量来实现的。
Consumption of brown rice and rice bran fermented withAspergillus oryzae(FBRA) suppresses spontaneously occurring diabetes in female NOD mouse. While control diet-fed mice showed glucosuria and hyperglycemia at around 20 week of age and the ratio reached to 57% at 30 weeks of age, the ratio did not increase in the 0.5% FBRA-containing diet-fed group. The FBRA-fed group at 30 weeks of age kept higher ratio of intact islets and showed significantly lower insulitis score compared to the control diet group, with dose-dependency from 0.25% to 0.5% dietary concentration of FBRA. The percentage of diabetic mice was significantly lower at 24 weeks of age as compared to the control group (p = 0.01, log rank test). These results indicate that the suppressive effects of dietary administration of 0.5% FBRA in delaying the spontaneous onset of diabetes in NOD mice is probably achieved by maintaining the number of intact islets.