Occupational Exposure to Dusts, Gases, and Fumes and Incidence of Chronic Obstructive Pulmonary Disease in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults
Occupational Exposure to Dusts, Gases, and Fumes and Incidence of Chronic Obstructive Pulmonary Disease in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults
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DOI：
10.1164/rccm.201110-1917oc
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发表时间：
2012-06-15
影响因子：
24.7
通讯作者：
Kuenzli, Nino
中科院分区：
文献类型：
--
作者：
Mehta, Amar J.;Miedinger, David;Kuenzli, Nino
目的：我们在瑞士空气污染与成人心肺疾病队列研究(SAPALDIA)中评估了职业暴露与COPD发病率之间的关系。测量和主要结果：测量和主要结果：在1991年基线和2001-2003年4,267名年龄18-62岁的非哮喘SAPALDIA参与者中，测量了1秒用力呼气量与用力肺活量之比(FEV1/FVC)。COPD由全球慢性阻塞性肺疾病倡议(GOLD)标准(FEV1/FVC<；0.70)和Quanjer参考方程(FEV1/FVC<；正常下限[LLN])定义，并按严重程度分类(=80%和=40年)，限制在非吸烟者时仍处于较高水平。结论：在瑞士工作的成年人口中，职业暴露于生物粉尘、矿物粉尘、气体/烟雾和VGDF与至少中度严重的COPD发病率有关。
Rationale: There is limited evidence from population-based studies demonstrating incidence of spirometric-defined chronic obstructive pulmonary disease (COPD) in association with occupational exposures.Objectives: We evaluated the association between occupational exposures and incidence of COPD in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA).Measurements and Main Results: Prebronchodilator ratio of forced expiratory volume in 1 second over forced vital capacity (FEV1/FVC) was measured in 4,267 nonasthmatic SAPALDIA participants ages 18-62 at baseline in 1991 and at follow-up in 2001-2003. COPD was defined by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criterion (FEV1/FVC < 0.70) and Quanjer reference equation (FEV1/FVC < lower limit of normal [LLN]), and categorized by severity (>= 80% and = 40 years, and remained elevated when restricted to nonsmokers.Conclusions: In a Swiss working adult population, occupational exposures to biological dusts, mineral dusts, gases/fumes, and VGDF were associated with incidence of COPD of at least moderate severity.