Social experience and social context alter the behavioral response to centrally administered oxytocin in female Syrian hamsters.
Social experience and social context alter the behavioral response to centrally administered oxytocin in female Syrian hamsters.
复制标题
社会经验和社会背景改变了雌性叙利亚仓鼠对集中注射催产素的行为反应。
DOI：
10.1016/s0306-4522(01)00523-1
复制
发表时间：
2002
期刊：
影响因子：
3.3
通讯作者：
Albers,HE
中科院分区：
文献类型：
--
作者：
Harmon,AC;Moore,TO;Huhman,KL;Albers,HE
个体表现出的社会行为类型深受其直接的社会环境或背景及其先前的社会经验的影响。虽然催产素在一些物种的社会行为表达中很重要，但尚不清楚社会因素是否会改变催产素影响行为的能力。本研究的目的是测试社会经验和社会环境改变催产素调节雌性叙利亚仓鼠侧腹标记（一种气味标记）的能力的假设。研究人员将催产素微注射到有社会经验的、占主导地位的雌性仓鼠内侧视前下丘脑前连续体（MPOA-AH）中，然后分别与下属伙伴、新伙伴或单独进行测试。催产素以剂量依赖的方式诱导侧腹标记，但仅当有经验的优势仓鼠与他们熟悉的，从属的伙伴进行测试时。当将催产素注射到与对手或单独进行测试的没有社交经验的雌性仓鼠体内时，催产素并没有引起腹部标记。相比之下，在雄性仓鼠中，当它们与从属伙伴或单独进行测试时，催产素会诱导优势仓鼠在腹部做标记。这些数据支持了社会经验和社会环境相互作用调节催产素通过其在雌性仓鼠MPOA-AH中的作用刺激侧腹标记的能力的假设。
The type of social behavior displayed by an individual is profoundly influenced by its immediate social environment or context and its prior social experience. Although oxytocin is important in the expression of social behavior in several species, it is not known if social factors alter the ability of oxytocin to influence behavior. The purpose of the present study was to test the hypothesis that social experience and social context alter the ability of oxytocin to regulate flank marking (a form of scent marking) in female Syrian hamsters. Oxytocin was microinjected into the medial preoptic anterior hypothalamic continuum (MPOA-AH) of socially experienced, dominant female hamsters which were then tested with either a subordinate partner, with a novel partner, or alone. Oxytocin induced flank marking in a dose-dependent manner but only when the experienced dominant hamsters were tested with their familiar, subordinate partners. Oxytocin did not induce flank marking when injected into socially naive female hamsters that were tested with an opponent or alone. In males, by contrast, oxytocin induced flank marking in dominant hamsters when they were tested with their subordinate partner or alone. These data support the hypothesis that social experience and social context interact to regulate the ability of oxytocin to stimulate flank marking by its actions in the MPOA-AH in female hamsters.