Stimulant-associated cognitive abnormalities: mechanisms and impact on reward-related behavior and addiction.
Stimulant-associated cognitive abnormalities: mechanisms and impact on reward-related behavior and addiction.
复制标题
兴奋剂相关的认知异常：奖励相关行为和成瘾的机制和影响。
DOI：
10.1016/j.drugalcdep.2008.05.003
复制
发表时间：
2008
影响因子：
4.2
通讯作者：
Kantak,KathleenM
中科院分区：
文献类型：
--
作者：
Kalechstein,AriD;Jentsch,JDavid;Kantak,KathleenM
在2007年CPDD会议上提出的一个专题讨论会介绍了兴奋剂成瘾的动物和人类模型的研究。这些研究结果强调了成瘾中神经认知障碍的相关性和机制基础。具体地说，我们讨论了大鼠和灵长类动物服用兴奋剂的神经认知后果。此外，对与兴奋剂使用相关的神经认知缺陷的人类研究结果进行了描述。总的来说，在啮齿类动物和非人类灵长类动物中，兴奋剂使用对大脑行为的影响是一个重点，这些讨论为药物治疗药物治疗兴奋剂依赖的研究奠定了基础。本次研讨会的内容是本次综述的主题。论文中提出的啮齿动物和非人类灵长类动物数据说明了使用动物成瘾模型来为人类研究中候选药物的选择提供信息的重要性。此外，这次演讲的初步数据显示，这些损伤实际上是可逆的。我们推测，这些研究提供了以前在兴奋剂成瘾治疗中未观察到的希望水平。（PsycINFO数据库记录(c) 2018 APA，版权所有）
A symposium presented at the 2007 CPDD meeting presents the studies of animal and human models of stimulant addiction. The findings from the studies presented highlight the relevance and mechanistic foundation of neurocognitive impairment in addiction. Specifically, the neurocognitive consequences of stimulant administration in rats and primates were discussed. Additionally, findings from human studies with respect to the neurocognitive deficits associated with stimulant use were described. Overall, there was a focus on the brain-behavior consequences of stimulant use in rodents and non-human primates, and these discussions set the stage for a proposal for the study of pharmacotherapeutic agents in the treatment of stimulant dependence. The content of this symposium is the subject of the current review. The rodent and non-human-primate data presented in the paper illustrate the importance of using animal models of addiction to inform the selection of candidate medications in human studies. Additionally, the preliminary data from this presentation reveal that these impairments are actually reversible. We speculate that such studies provide a level of promise not previously observed in the treatment of stimulant addicts.(PsycINFO Database Record (c) 2018 APA, all rights reserved)