Notch-mediated lateral inhibition regulates proneural wave propagation when combined with EGF-mediated reaction diffusion
Notch-mediated lateral inhibition regulates proneural wave propagation when combined with EGF-mediated reaction diffusion
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DOI：
10.1073/pnas.1602739113
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发表时间：
2016-08-30
影响因子：
11.1
通讯作者：
Nagayama, Masaharu
中科院分区：
文献类型：
--
作者：
Sato, Makoto;Yasugi, Tetsuo;Nagayama, Masaharu
Notch介导的侧抑制调节二元细胞命运选择，导致在各种发育过程中的盐和胡椒模式。然而，Notch信号传导如何与其他信号传导系统结合仍然难以捉摸。果蝇视觉中心的分化波或“前神经波”伴随着Notch活动，该活动在没有形成盐和胡椒图案的情况下传播，这意味着Notch在此过程中不会形成侧抑制的反馈回路。然而，数学建模和遗传分析清楚地表明，Notch介导的侧抑制是在前神经波内实现的。由于EGF信号传导的部分减少导致盐和胡椒模式的形成，因此EGF扩散最有可能在计算机模拟和体内取消盐和胡椒模式的形成。此外，Notch介导的侧向抑制和EGF介导的反应扩散的组合使得Notch信号传导的功能能够调节分化波的传播。
Notch-mediated lateral inhibition regulates binary cell fate choice, resulting in salt and pepper patterns during various developmental processes. However, how Notch signaling behaves in combination with other signaling systems remains elusive. The wave of differentiation in the Drosophila visual center or "proneural wave" accompanies Notch activity that is propagated without the formation of a salt and pepper pattern, implying that Notch does not form a feedback loop of lateral inhibition during this process. However, mathematical modeling and genetic analysis clearly showed that Notch-mediated lateral inhibition is implemented within the proneural wave. Because partial reduction in EGF signaling causes the formation of the salt and pepper pattern, it is most likely that EGF diffusion cancels salt and pepper pattern formation in silico and in vivo. Moreover, the combination of Notch-mediated lateral inhibition and EGF-mediated reaction diffusion enables a function of Notch signaling that regulates propagation of the wave of differentiation.