Survival assays using Caenorhabditis elegans.
Survival assays using Caenorhabditis elegans.
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DOI：
10.14348/molcells.2017.0017
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发表时间：
2017-02
影响因子：
3.8
通讯作者：
Lee SV
中科院分区：
文献类型：
--
作者：
Park HH;Jung Y;Lee SV
秀丽隐杆线虫是一种重要的模式生物，具有发育和衰老快、易培养、遗传易处理等特点。使用C.线虫是研究生理过程的有力工具。在这篇综述中，我们描述了不同类型的C。线虫生存测定和讨论的目的，用途，和特定的测定的优点。C.线虫存活测定在鉴定调节动物生理学的许多方面（如衰老和寿命、应激反应和对病原体的免疫力）的新遗传因子方面发挥了关键作用。由于许多遗传因素的发现，利用C。虽然线虫在进化上是保守的，但存活测定可以提供对哺乳动物（包括人类）生理过程的潜在机制的见解。
Caenorhabditis elegans is an important model organism with many useful features, including rapid development and aging, easy cultivation, and genetic tractability. Survival assays using C. elegans are powerful methods for studying physiological processes. In this review, we describe diverse types of C. elegans survival assays and discuss the aims, uses, and advantages of specific assays. C. elegans survival assays have played key roles in identifying novel genetic factors that regulate many aspects of animal physiology, such as aging and lifespan, stress response, and immunity against pathogens. Because many genetic factors discovered using C. elegans are evolutionarily conserved, survival assays can provide insights into mechanisms underlying physiological processes in mammals, including humans.