Is There a Relationship Between Mating and Pathogenesis in Two Human Fungal Pathogens, Candida albicans and Candida glabrata?
Is There a Relationship Between Mating and Pathogenesis in Two Human Fungal Pathogens, Candida albicans and Candida glabrata?
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DOI：
10.1007/s40588-023-00192-8
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发表时间：
2023
影响因子：
5.2
通讯作者：
Usher, Jane
中科院分区：
文献类型：
--
作者：
Bedekovic, Tina;Usher, Jane
人类真菌病原体的发病率正在迅速增加，并且很容易逃避宿主的免疫反应。由于明显缺乏性周期和前向遗传工具，我们研究其背后遗传的能力受到限制。在这篇综述中，我们讨论了交配、减数分裂和发病机制的进化，以及这些过程是否对病原体有利。这篇综述总结了目前对两种重要人类真菌病原体——白色念珠菌和光滑念珠菌——性周期的了解。这包括白色念珠菌中准有性周期的鉴定以及光滑念珠菌种群中观察到的低水平重组。在这篇综述中，我们介绍了目前已知的两种临床上重要的人类真菌病原体——白色念珠菌和光滑念珠菌——的交配类型和交配/性周期。我们利用几十年来研究酿酒酵母所积累的知识来讨论减数分裂的进化，以及如何将其应用于真菌病原体。我们进一步讨论发病机制的进化如何在影响人类真菌病原体的交配过程中发挥作用，并比较白色念珠菌和光滑念珠菌之间的性周期，突出知识差距并表明这两种真菌如何进化出不同的交配生态位以允许人类宿主疾病的发展。
Human fungal pathogens are rapidly increasing in incidence and readily able to evade the host immune responses. Our ability to study the genetic behind this has been limited due to the apparent lack of a sexual cycle and forward genetic tools. In this review, we discuss the evolution of mating, meiosis, and pathogenesis and if these processes are advantageous to pathogens. This review summarises what is currently known about the sexual cycles of two important human fungal pathogens, Candida albicans and Candida glabrata. This includes the identification of parasexual cycle in C. albicans and the observed low levels of recombination in C. glabrata populations. In this review, we present what is currently known about the mating types and mating/sexual cycles of two clinically important human fungal pathogens, Candida albicans and Candida glabrata. We discuss the evolution of meiosis using the knowledge that has been amassed from the decades of studying Saccharomyces cerevisiae and how this can be applied to fungal pathogens. We further discuss how the evolution of pathogenesis has played a role in influencing mating processes in human fungal pathogens and compare sexual cycles between C. albicans and C. glabrata, highlighting knowledge gaps and suggesting how these two fungi have evolved distinct mating niches to allow the development of disease in a human host.
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DOI：
10.1073/pnas.0304170101
发表时间：
2004-02-10
影响因子：
11.1
作者：
Butler, G;Kenny, C;Wolfe, KH
通讯作者：
Wolfe, KH
影响因子：
5.3
作者：
HAGEN, DC;BRUHN, L;SPRAGUE, GF
通讯作者：
SPRAGUE, GF
影响因子：
3.4
作者：
Ciudad, Toni;Bellido, Alberto;Larriba, German
通讯作者：
Larriba, German
影响因子：
9.8
作者：
Forche A;Alby K;Schaefer D;Johnson AD;Berman J;Bennett RJ
通讯作者：
Bennett RJ
影响因子：
3.3
作者：
Haber, James E.
通讯作者：
Haber, James E.