Reply to the ‘Comment on “Tensional homeostasis at different length scales” by J. Humphrey and C. Cyron, Soft Matter , 2022, 18 , DOI: 10.1039/D1SM01151K’
Reply to the ‘Comment on “Tensional homeostasis at different length scales” by J. Humphrey and C. Cyron, Soft Matter , 2022, 18 , DOI: 10.1039/D1SM01151K’
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回复 J. Humphrey 和 C. Cyron 对“不同长度尺度下的张力稳态的评论”，Soft Matter，2022, 18，DOI: 10.1039/D1SM01151K —
DOI：
10.1039/d1sm01495a
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发表时间：
2022
期刊：
影响因子：
3.4
通讯作者：
Smith, Michael L.
中科院分区：
文献类型：
--
作者：
Stamenović, Dimitrije;Smith, Michael L.
Drs Humphrey和Cyron就我们发表在Soft Matter，2020，16，6946-6963上的题为“Tensional homeostasis at different length scales”的评论文章写了评论。这些作者提出了一些合理的关切，我们希望对此作出回应。他们的第一个关注点与我们对用于描述血管内稳态的方程的评论有关，我们指出这些方程仅限于线性弹性材料。我们错了，我们同意作者的观点，即这些方程适用于所有圆柱形容器，而不管它们的材料特性如何。他们的第二个关注点与亚细胞水平的张力稳态有关。Humphrey和Cyron博士不同意我们已经证实的主张，即张力稳态在活细胞的粘着斑（FAs）水平上被破坏。在我们的回复中，我们提供了几条证据，证明张力稳态取决于FA大小，FA成熟度和FA力动力学，因此，张力稳态不能在整个细胞的所有FA中保持。总之，我们感谢有机会对汉弗莱博士和塞隆博士的评论作出答复。此外，我们很高兴这个话题已经成为生物力学和机械生物学社区的一个重要焦点，我们强烈认为，关键的反馈是必要的，以推动这一领域的发展。
Drs Humphrey and Cyron wrote a commentary regarding our review article entitled “Tensional homeostasis at different length scales” that was published in Soft Matter, 2020, 16, 6946–6963. These authors brought up some valid concerns to which we would like to respond. Their first concern is related to our remark regarding equations that we used to describe homeostasis in blood vessels, where we stated that those equations were limited only to linearly elastic materials. We were wrong, and we agree with the authors that these equations hold for all cylindrical vessels regardless of their material properties. Their second concern is related to tensional homeostasis at the subcellular level. Drs Humphrey and Cyron disagree with our substantiated claim that tensional homeostasis breaks down at the level of focal adhesions (FAs) of a living cell. In our reply, we provided several pieces of evidence that demonstrate that tensional homeostasis depends upon FA size, FA maturity and FA force dynamics and thus, tensional homeostasis cannot hold in all FAs across a cell. In summary, we are grateful for the opportunity to reply to the commentary of Drs Humphrey and Cyron. Moreover, we are excited that this topic has become an important focus in the biomechanics and mechanobiology communities, and we feel strongly that critical feedback is necessary to move this field forward.