Gut microbiota in patients with Parkinson's disease in southern China
Gut microbiota in patients with Parkinson's disease in southern China
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DOI：
10.1016/j.parkreldis.2018.05.007
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发表时间：
2018-08-01
影响因子：
4.1
通讯作者：
Xie, Huifang
中科院分区：
文献类型：
--
作者：
Lin, Aiqun;Zheng, Wenxia;Xie, Huifang
前言越来越多的证据表明帕金森病(PD)患者肠道和脑之间的通讯发生了改变，先前的研究证实肠道微生物群的改变在包括帕金森病在内的许多疾病的发病机制中起着重要作用。本研究的目的是确定中国南部地区帕金森病患者的粪便微生物区系是否与对照组有所不同，以及不同的帕金森病患者的运动表型之间肠道微生物区系组成是否存在差异。方法：采用16SRRNA下一代测序技术对75例帕金森病患者和45例年龄匹配的对照组的肠道微生物区系组成进行比较。结果：与对照组相比，帕金森病患者的4个细菌系的丰度显著增加，17个细菌系的丰度显著降低。尤其是帕金森病患者沙棘科细菌的丰度降低了42.9%，而双歧杆菌科细菌的丰度在帕金森病患者中有所增加。我们没有发现不同PD电机表型之间总体微生物组成的显著差异，但我们确定了特定紫杉醇与不同PD电机表型之间的关联。结论：PD伴随着特定肠道微生物丰度的变化。某些肠道微生物的丰度取决于临床运动表型的改变。根据我们的发现，肠道微生物组可能是潜在的帕金森病生物标志物。
Introduction Accumulating evidence has revealed alterations in the communication between the gut and brain in patients with Parkinson's disease (PD), and previous studies have confirmed that alterations in the gut microbiome play an important role in the pathogenesis of numerous diseases, including PD. The aim of this study was to determine whether the faecal microbiome of PD patients in southern China differs from that of control subjects and whether the gut microbiome composition alters among different PD motor phenotypes.Methods: We compared the gut microbiota composition of 75 patients with PD and 45 age-matched controls using 16S rRNA next-generation-sequencing.Results: We observed significant increases in the abundance of four bacterial families and significant decreases in the abundance of seventeen bacterial families in patients with PD compared to those of the controls. In particular, the abundance of Lachnospiraceae was reduced by 42.9% in patients with PD, whereas Bifidobacteriaceae was enriched in patients with PD. We did not identify a significant difference in the overall microbial composition among different PD motor phenotypes, but we identified the association between specific taxas and different PD motor phenotypes.Conclusions: PD is accompanied by alterations in the abundance of specific gut microbes. The abundance of certain gut microbes was altered depending on clinical motor phenotypes. Based on our findings, the gut microbiome may be a potential PD biomarker.