Toluene derivatives as simple coupling precursors for cascade palladium-catalyzed oxidative C-H bond acylation of acetanilides.
Toluene derivatives as simple coupling precursors for cascade palladium-catalyzed oxidative C-H bond acylation of acetanilides.
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DOI：
10.1039/c2cc37352a
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发表时间：
2013-01
影响因子：
4.9
通讯作者：
Yinuo Wu;P. Choy;F. Mao;F. Kwong
中科院分区：
文献类型：
--
作者：
Yinuo Wu;P. Choy;F. Mao;F. Kwong
研究了钯催化的乙酰苯胺与甲苯级联交叉偶联反应合成邻酰基乙酰苯胺的反应。在两个C-H键之间的氧化偶联反应中，甲苯衍生物可以作为有效的酰基前体(在Pd/TBHP体系中氧化sp(3)-C-H键)。该脱氢Pd催化的邻酰化反应在温和的反应条件下进行。
A palladium-catalyzed cascade cross-coupling of acetanilide and toluene for the synthesis of ortho-acylacetanilide is described. Toluene derivatives can act as effective acyl precursors (upon sp(3)-C-H bond oxidation by a Pd/TBHP system) in the oxidative coupling between two C-H bonds. This dehydrogenative Pd-catalyzed ortho-acylation proceeds under mild reaction conditions.