Gender differences in Alzheimer's may be associated with TLR4-LYN expression in damage associated microglia and neuronal phagocytosis.
Gender differences in Alzheimer's may be associated with TLR4-LYN expression in damage associated microglia and neuronal phagocytosis.
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DOI：
10.1002/jcp.30916
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发表时间：
2022-11
影响因子：
5.6
通讯作者：
R. Islam;Robin Rajan;Hadi Choudhary;F. Vrionis;Khalid A. Hanafy
中科院分区：
文献类型：
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作者：
R. Islam;Robin Rajan;Hadi Choudhary;F. Vrionis;Khalid A. Hanafy
由于许多针对这些沉积物的药物制剂失败以及在正常人脑中检测到这些错误折叠的蛋白质，Aβ斑块和神经原纤维缠结在阿尔茨海默病（AD）发病机制中的作用最近受到质疑。因此，我们在AD小鼠模型中研究了小胶质细胞活化与Toll样受体4（TLR 4）和Lck/Yes新型酪氨酸（林恩）激酶信号传导之间的相关性。
The role of Aβ plaques and neurofibrillary tangles in Alzheimer's disease (AD) pathogenesis have recently come into question due to failure of many pharmaceutical agents targeting these deposits and detection of these misfolded proteins in normal human brains. Therefore, we investigated correlations between microglial activation and toll like receptor 4 (TLR4) and Lck/Yes novel tyrosine (LYN) kinase signaling in an AD mouse model.