Transcriptional factors in the cochlea within the inner ear
Transcriptional factors in the cochlea within the inner ear
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DOI：
10.1254/jphs.cpj05004x
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发表时间：
2005-12-01
影响因子：
3.5
通讯作者：
Ogita, K
中科院分区：
文献类型：
--
作者：
Nagashima, R;Sugiyama, C;Ogita, K
转录因子对基因表达的差异调控被广泛认为是指导发育的主要机制之一。虽然已经在各种组织中发现了大量的DNA结合蛋白，但单个转录因子在特定细胞组分化中的作用才刚刚开始阐明，例如那些位于内耳的细胞组。众所周知，转录因子是在多种信号作用下被诱导的，这些信号导致细胞生长、分化、炎症反应、细胞凋亡调节和肿瘤转化。内耳的耳蜗里有各种转录因子。其中包括激活蛋白-1和核因子-kappaB、糖皮质激素受体等。根据最近的报道和我们的研究，本文综述了这些转录因子的可能功能和表达。
Differential regulation of gene expression by transcription factors is widely viewed as one of the principal mechanisms guiding development. Although numerous DNA binding proteins have been identified in various tissues, the role of individual transcription factors in the differentiation of specific cell groups, such as those populating the inner ear, is just beginning to be elucidated. It is known that transcription factors are induced in response to many signals that lead to cell growth, differentiation, inflammatory responses, the regulation of apoptosis, and neoplastic transformation. There are various transcription factors in the cochlea of the inner ear. These include activator protein-1 and nuclear factor-kappa B, glucocorticoid receptor, and so on. Based on recent reports and our investigation, in this article we review possible functions and expression of these transcription factors.