Familial Papillary Thyroid Carcinoma: A Retrospective Analysis
Familial Papillary Thyroid Carcinoma: A Retrospective Analysis
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DOI：
10.1155/2011/948786
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发表时间：
2011-01-01
影响因子：
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通讯作者：
Malchoff, Carl D.
中科院分区：
文献类型：
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作者：
McDonald, Thomas J.;Driedger, Albert A.;Malchoff, Carl D.
背景资料。家族性乳头状甲状腺癌是否比散发性甲状腺癌更具侵袭性仍存在争议。方法：研究方法。为了探讨这一问题，以及在有多个受累成员的家族中是否更明显地增加侵袭性，我们对我们的患者的临床和病理数据进行了趋势分析的卡方检验：有三个或更多受累成员的一级家庭与有两个受累成员的一级家庭相比，散发性乳头状甲状腺癌患者的侵袭性是否更明显。结果。在任何呈现的手术病理参数、发病年龄、随访时间或性别分布方面，均未见有统计学意义的趋势。家族组再手术率(P=0.003.0 5)和(或)需加碘治疗(P=0.0 3)、远处转移(P=0.0 5)和死亡率(P=0.0 1)有显著差异。这些攻击性特征在某些有三个或更多受影响成员的家庭中最为明显。结论。趋势分析的卡方检验显示，家族性乳头状甲状腺癌比散发性甲状腺癌具有更多的侵袭性特征。及时认识到这种疾病的家族性可能会为同样受到影响的家庭成员提供更早的诊断和治疗。
Background. Whether or not the familial form of papillary thyroid carcinoma is more aggressive than the sporadic form of the disease remains controversial. Methods. To explore this question and whether or not increased aggressiveness is more apparent in families with multiple affected members, we performed a chi square by trend analysis on our patients clinical and pathologic data comparing: first degree families with three or more affectedmembers versus first degree families with two affectedmembers versus sporadic cases of papillary thyroid carcinoma. Results. No statistically significant trends were seen for any presenting surgical pathology parameter, age at presentation, length of follow-up or gender distribution. The familial groups exhibited significant trends for higher rates of reoperation (P = 0.05) and/or requiring additional radioactive iodine therapy (P = 0.03), distant metastases (P = 0.003) and deaths (P = 0.01). These aggressive features were most apparent in certain families with three or more affected members. Conclusions. Using the chi square by trend analysis, a significant trend was seen for the familial form of papillary thyroid cancer to possess more aggressive features than the sporadic disease. Prompt recognition of the familial nature of the disease may provide earlier diagnosis and treatment in similarly affected family members.