Analysis of CT features and quantitative texture analysis in patients with thymic tumors: correlation with grading and staging
Analysis of CT features and quantitative texture analysis in patients with thymic tumors: correlation with grading and staging
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DOI：
10.1007/s11547-017-0845-4
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发表时间：
2018-05-01
影响因子：
8.9
通讯作者：
Catalano, Carlo
中科院分区：
文献类型：
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作者：
Iannarelli, Angelo;Sacconi, Beatrice;Catalano, Carlo
探讨胸腺肿瘤患者的定性CT特征、定量质构分析（QTA）、组织学、WHO分期、Masaoka分型与肌无力综合征的潜在关系。16例经组织学证实的胸腺肿瘤患者被回顾性纳入研究人群。记录临床信息，特别是肌无力综合征和抗achr抗体的血清学阳性。定性CT评价包括以下参数：(a)位置；(b)肿瘤边缘；(c)坏死;(d)胸腔积液；(e)转移;(f)胸壁浸润；(g)肿瘤边缘。QTA包括“均值”(M)、“标准差”（SD）、“峰度”(K)、“偏度”(S)、“熵”(E)、“纹理形状”（TX_sigma）和“正像素平均值”（MPP）的评估。连续非二分类参数间的关系采用Pearson-Rho检验，二分类参数间的关系采用Mann-Whitney检验。组织学检查显示胸腺瘤12例，胸腺癌4例。肿瘤坏死与QTA Mean （p = 0.0253）、MPP （p = 0.0417）、S （p = 0.0488）、K （p = 0.0178）显著相关。WHO分期与Mean （p = 0.0193）、SD （p = 0.0191）、MPP （p = 0.0195）相关。Masaoka分类与Mean （p = 0.0322）、MPP （p = 0.0315）、skeness （p = 0.0433）、Kurtosis （p = 0.0083）相关。肌无力综合征与Mean （p = 0.0211）和MPP （p = 0.0261）相关，而肿瘤大小与Mean （p = 0.0241）、熵（p = 0.0177）、MPP （p = 0.0468）、偏度（p = 0.009）和峰度（p = 0.006）相关。我们的研究表明胸腺肿瘤的放射组学参数、组织学、分级和临床表现之间有显著的关系。
To evaluate potential relationship between qualitative CT features, quantitative texture analysis (QTA), histology, WHO staging, Masaoka classification and myasthenic syndrome in patients with thymic tumors.Sixteen patients affected by histologically proven thymic tumors were retrospectively included in the study population. Clinical information, with special regard to myasthenic syndrome and serological positivity of anti-AchR antibodies, were recorded. Qualitative CT evaluation included the following parameters: (a) location; (b) tumor edges; (c) necrosis; (d) pleural effusion; (e) metastases; (f) chest wall infiltration; (g) tumor margins. QTA included evaluation of "Mean" (M), "Standard Deviation" (SD), "Kurtosis" (K), "Skewness" (S), "Entropy" (E), "Shape from Texture" (TX_sigma) and "average of positive pixels" (MPP). Pearson-Rho test was used to evaluate the relationship of continuous non-dichotomic parameters, whereas Mann-Whitney test was used for dichotomic parameters.Histological evaluation demonstrated thymoma in 12 cases and thymic carcinoma in 4 cases. Tumor necrosis was significantly correlated with QTA Mean (p = 0.0253), MPP (p = 0.0417), S (p = 0.0488) and K (p = 0.0178). WHO staging was correlated with Mean (p = 0.0193), SD (p = 0.0191) and MPP (p = 0.0195). Masaoka classification was correlated with Mean (p = 0.0322), MPP (p = 0.0315), skewness (p = 0.0433) and Kurtosis (p = 0.0083). Myasthenic syndrome was significantly associated with Mean (p = 0.0211) and MPP (p = 0.0261), whereas tumor size was correlated with Mean (p = 0.0241), entropy (p = 0.0177), MPP (p = 0.0468), skewness (p = 0.009) and Kurtosis (p = 0.006).Our study demonstrates significant relationship between radiomics parameters, histology, grading and clinical manifestations of thymic tumors.