Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment.
Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment.
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DOI：
10.1038/nn.4553
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发表时间：
2017-06
影响因子：
25
通讯作者：
Tye KM
中科院分区：
文献类型：
--
作者：
Burgos-Robles A;Kimchi EY;Izadmehr EM;Porzenheim MJ;Ramos-Guasp WA;Nieh EH;Felix-Ortiz AC;Namburi P;Leppla CA;Presbrey KN;Anandalingam KK;Pagan-Rivera PA;Anahtar M;Beyeler A;Tye KM
面对预测环境中回报或威胁的相互竞争的信号，协调适当的行为反应对生存至关重要。杏仁基底外侧核(BLA)和前额叶内侧皮质(PL)与寻求奖赏和恐惧相关的反应有关，但信息如何在这些相互连接的结构之间流动以协调行为尚不清楚。我们记录了BLA和PL的神经元活动，当大鼠执行一项任务时，休克和蔗糖预测线索同时呈现以诱导竞争。相关放电在电击相关线索中主要表现为Bla→PL的方向性。此外，记录到的大多数光遗传学识别的投射PL的BLA神经元编码了与休克相关的线索，并比未识别的BLA神经元更准确地预测了竞争过程中的行为反应。最后，Bla→PL光刺激增加了冰冻，而化学发生和光发生抑制都减少了冰冻。在面对相互竞争的信号时，Bla→PL电路在控制行为反应的选择方面发挥着关键作用。
Orchestrating appropriate behavioral responses in the face of competing signals that predict either rewards or threats in the environment is crucial for survival. The basolateral amygdala (BLA) and prelimbic (PL) medial prefrontal cortex (mPFC) have been implicated in reward-seeking and fear-related responses, but how information flows between these reciprocally-connected structures to coordinate behavior is unknown. We recorded neuronal activity from the BLA and PL while rats performed a task where in shock- and sucrose-predictive cues were simultaneously presented to induce competition. The correlated firing primarily displayed a BLA→PL directionality during the shock-associated cue. Furthermore, the majority of optogenetically-identified PL-projecting BLA neurons recorded encoded the shock-associated cue, and more accurately predicted behavioral responses during competition than unidentified BLA neurons. Finally, BLA→PL photostimulation increased freezing, whereas both chemogenetic and optogenetic inhibition reduced freezing. The BLA→PL circuit plays a critical role in governing the selection of behavioral responses in the face of competing signals.