KINETICS AND METABOLISM OF AMPHETAMINE IN BRAIN OF RATS OF DIFFERENT AGES
KINETICS AND METABOLISM OF AMPHETAMINE IN BRAIN OF RATS OF DIFFERENT AGES
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DOI：
10.1007/bf00500043
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发表时间：
1975-01-01
影响因子：
3.6
通讯作者：
COPER, H
中科院分区：
文献类型：
--
作者：
HONECKER, H;COPER, H
研究了幼龄（3-4月龄）和老年（20-25月龄）雄性大鼠经5 mg/kg氚标记安非他明后，安非他明及其代谢产物-羟安非他明（p-OH-A）和-羟去甲麻黄碱（p-OH-NE）的动力学和组织分布。采用薄层色谱法测定大鼠血浆、大脑皮层、脑干和下丘脑中药物的浓度。注射安非他命后60min ~ 4h，老龄大鼠血浆和脑组织中a非他命浓度显著高于年轻成年大鼠（P<0.05）。在两个年龄组中，安非他明在大脑皮层、脑干和下丘脑的水平。血脑屏障是top-OH-A；静脉注射10 μCi/kg （10 mCi/m mol）后10 ~ 20 min，脑/血浆比例为1:3。2 .注射安非他命后血浆中对羟基苯甲酸半衰期与注射安非他命后对羟基苯甲酸半衰期几乎相同（分别为90 min和98 min）。应用安非他明4 h后，老龄大鼠各脑区P - oh - ne水平显著低于年轻成年大鼠（P<0.05）。这种安非他明的代谢物在下丘脑的浓度比在大脑其他区域的浓度更早。
The kinetics and tissue distribution of amphetamine and its metabolitesp-hydroxyamphetamine (p-OH-A) andp-hydroxynorephedrine (p-OH-NE) were investigated in young adult (3–4 months) and old (20–25 months) male rats, after i.p. injection of 5 mg/kg tritium labelledd-amphetamine. The concentrations of these drugs were determined in plasma, cerebral cortex, brainstem and hypothalamus, by thin layer chromatography.1.From 60 min up to 4 hrs after injection of amphetamine the concentration of a mphetamine in plasma and brain tissue of old rats was significantly (P<0.05 higher than in young adult animals. In both age groups the levels of amphetamine in cerebral cortex > brain stem > hypothalamus.2.The blood-brain barrier is permutle top-OH-A; 10 to 20 min after i.v. injection of 10 μCi/kg ofp-OH-A (10 mCi/m mole) the ratio brain/blood plasma was found to be 1:3. The half life ofp-OH-A in blood plasma was almost identical after injection of amphetamine andp-OH-A (90 min and 98 min respectively).3.The levels ofp-OH-NE in different brain areas were significantly lower (P<0.05) in old animals than in young adult rats 4 hrs after application of amphetamine. This metabolite of amphetamine shows a higher concentration in the hypothalamus earlier than in other brain regions.