Early and chronic stress and their relation to breast cancer
Early and chronic stress and their relation to breast cancer
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DOI：
10.1017/s0033291799002020
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发表时间：
2000-05-01
影响因子：
6.9
通讯作者：
Bovasso, GB
中科院分区：
文献类型：
--
作者：
Jacobs, JR;Bovasso, GB
背景。该研究调查了父母死亡和慢性抑郁症严重发作对乳腺癌风险的影响。这一研究途径与肿瘤学的发现是一致的，这些发现表明乳腺癌的致病因素在20年或更长时间内发生和发展。参与者包括巴尔的摩流行病学集水区研究的1213名妇女，于1980年接受调查，并随访至1994-1995年。研究人员评估了他们的抑郁和焦虑障碍、童年时期父亲死亡以及癌症住院前相对近期的不良生活事件。在研究过程中，29名妇女因乳腺癌住院，10人死于乳腺癌。预测乳腺癌风险增加的社会心理变量是儿童期产妇死亡（OR = 2.56, P < 0.001）和重度慢性抑郁症（OR = 14.0, P < 0.001）。最近的生活事件和其他抑郁和焦虑障碍都与风险增加无关。据报道，至少在乳腺癌住院前20年就有产妇死亡和慢性抑郁症的严重发作。产妇死亡和慢性和严重抑郁症至少发生在乳腺癌住院治疗前20年，可能是导致或促进癌症发展的原因之一。作者建议，需要对其他前瞻性研究进行荟萃分析，以创建更大的具有这些压力的个体群体，以自信地将这些变量确定为风险因素。
Background. The study examined the role of parental death and chronic depression with severe episodes in affecting risk of breast cancer. This avenue of research is in accord with oncology findings, which suggests that causative factors of breast cancer occur and develop over a period of 20 years or longer.Methods. Participants consisted of 1213 women in the Baltimore Epidemiologic Catchment Area study surveyed in 1980 and followed through 1994-1995. They were assessed for depressive and anxious disorders, paternal death in childhood and relatively recent adverse life events prior to cancer hospitalization.Results. In the course of the study, 29 women were hospitalized for breast cancer and 10 died of breast cancer. The psychosocial variables that predicted increased risk of breast cancer were maternal death in childhood (OR = 2.56, P < 0.001) and chronic depression with severe episodes (OR = 14.0, P < 0.001). Neither relatively recent life events nor other depressive and anxiety disorders were associated with increased risk. Maternal death and chronic depression with severe episodes were reported to have occurred at least 20 years prior to breast cancer hospitalization.Conclusions. Maternal death and chronic and severe depression occurred at least 20 years prior to breast cancer hospitalization and could have been involved in the causation or facilitation of cancer development. The authors suggest that meta-analysis of other prospective studies are needed to create larger groups of individuals with these stresses to confidently establish these variables as risk factors.