Strong Relationship Between Vascular Function in the Coronary and Brachial Arteries A Clinical Coming of Age for the Updated Flow-Mediated Dilation Test?
Strong Relationship Between Vascular Function in the Coronary and Brachial Arteries A Clinical Coming of Age for the Updated Flow-Mediated Dilation Test?
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DOI：
10.1161/hypertensionaha.119.12881
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发表时间：
2019-07-01
期刊：
影响因子：
8.3
通讯作者：
Richardson, Russell S.
中科院分区：
文献类型：
--
作者：
Broxterman, Ryan M.;Witman, Melissa A.;Richardson, Russell S.
冠状动脉功能障碍的早期检测具有重要的心血管临床意义，但缺乏无创性评估。事实上，肱动脉血流介导的舒张试验与乙酰胆碱诱导的冠状动脉功能仅弱相关（r=0.36）。然而，随着时间的推移，肱动脉血流介导的扩张方法已经得到了实质性的改进。本研究旨在确定该技术的更新是否改善了与冠状动脉功能和冠状动脉功能障碍的无创适应症的关系。对28例接受心导管检查的患者（61 ± 11岁）进行了冠状动脉和肱动脉功能评估。冠状动脉功能通过冠状动脉内注入1.82 μ g/min乙酰胆碱后动脉直径的变化来确定。根据血管直径的变化，患者的特征为冠状动脉功能障碍（>5%血管收缩）或冠状动脉功能相对正常（
Early detection of coronary artery dysfunction is of paramount cardiovascular clinical importance, but a noninvasive assessment is lacking. Indeed, the brachial artery flow-mediated dilation test only weakly correlated with acetylcholine-induced coronary artery function (r=0.36). However, brachial artery flow-mediated dilation methodologies have, over time, substantially improved. This study sought to determine if updates to this technique have improved the relationship with coronary artery function and the noninvasive indication of coronary artery dysfunction. Coronary artery and brachial artery function were assessed in 28 patients referred for cardiac catheterization (61 +/- 11 years). Coronary artery function was determined by the change in artery diameter with a 1.82 mu g/min intracoronary acetylcholine infusion. Based on the change in vessel diameter, patients were characterized as having dysfunctional coronary arteries (>5% vasoconstriction) or relatively functional coronary arteries (