Demyelination of the Optic Nerve: An Underlying Factor in Glaucoma?
Demyelination of the Optic Nerve: An Underlying Factor in Glaucoma?
复制标题
视神经脱髓鞘：青光眼的潜在因素？
DOI：
10.3389/fnagi.2021.701322
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发表时间：
2021
影响因子：
4.8
通讯作者：
Zhuo Y
中科院分区：
文献类型：
--
作者：
Xue J;Zhu Y;Liu Z;Lin J;Li Y;Li Y;Zhuo Y
Neurodegenerative disorders are characterized by typical neuronal degeneration and axonal loss in the central nervous system (CNS). Demyelination occurs when myelin or oligodendrocytes experience damage. Pathological changes in demyelination contribute to neurodegenerative diseases and worsen clinical symptoms during disease progression. Glaucoma is a neurodegenerative disease characterized by progressive degeneration of retinal ganglion cells (RGCs) and the optic nerve. Since it is not yet well understood, we hypothesized that demyelination could play a significant role in glaucoma. Therefore, this study started with the morphological and functional manifestations of demyelination in the CNS. Then, we discussed the main mechanisms of demyelination in terms of oxidative stress, mitochondrial damage, and immuno-inflammatory responses. Finally, we summarized the existing research on the relationship between optic nerve demyelination and glaucoma, aiming to inspire effective treatment plans for glaucoma in the future.
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影响因子：
5.6
作者：
Ambrosius W;Michalak S;Kozubski W;Kalinowska A
通讯作者：
Kalinowska A
影响因子：
17.8
作者：
De Moraes CG;Liebmann JM;Levin LA
通讯作者：
Levin LA
影响因子：
7.3
作者：
Donegan RK;Lieberman RL
通讯作者：
Lieberman RL
DOI：
10.1073/pnas.1808064115
发表时间：
2018-12-11
影响因子：
11.1
作者：
Duncan, Ian D.;Radcliff, Abigail B.;Wierenga, Lauren A.
通讯作者：
Wierenga, Lauren A.
通过电子显微镜研究的小鼠和大鼠中枢神经系统中髓磷脂的形成。
DOI：
10.1083/jcb.2.6.777
发表时间：
1956-11-25
期刊：
The Journal of biophysical and biochemical cytology
影响因子：
--
作者：
LUSE, S A
通讯作者：
LUSE, S A