Neural control of phrenic motoneuron discharge.
Neural control of phrenic motoneuron discharge.
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DOI：
10.1016/j.resp.2011.02.014
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发表时间：
2011-10-15
影响因子：
2.3
通讯作者：
Fuller DD
中科院分区：
文献类型：
--
作者：
Lee KZ;Fuller DD
膈运动神经元（PMNs）在延髓脊髓呼吸通路和膈肌之间提供突触中继。中性粒细胞也接受propriospinal输入，虽然这些神经元间的预测功能的作用还没有建立。在这里，我们回顾了有关呼吸过程中的PMN放电模式和潜在的机制，PMN招聘的文献。解剖学和神经生理学研究表明，中性粒细胞形成一个异质性池，与突触相关的中性粒细胞放电和招聘模式可能由内在MN属性和外在突触输入之间的平衡决定。我们还回顾了有限的文献中关于呼吸可塑性的PMN爆发。中性粒细胞亚型的差异募集或速率调节可能是神经损伤和/或呼吸刺激后膈运动可塑性的基础;然而，这种可能性仍然相对未被探索。
Phrenic motoneurons (PMNs) provide a synaptic relay between bulbospinal respiratory pathways and the diaphragm muscle. PMNs also receive propriospinal inputs, although the functional role of these interneuronal projections has not been established. Here we review the literature regarding PMN discharge patterns during breathing and the potential mechanisms that underlie PMN recruitment. Anatomical and neurophysiological studies indicate that PMNs form a heterogeneous pool, with respiratory-related PMN discharge and recruitment patterns likely determined by a balance between intrinsic MN properties and extrinsic synaptic inputs. We also review the limited literature regarding PMN bursting during respiratory plasticity. Differential recruitment or rate modulation of PMN subtypes may underlie phrenic motor plasticity following neural injury and/or respiratory stimulation; however this possibility remains relatively unexplored.