Serum levels of innate immunity cytokines are elevated in dogs with metaphyseal osteopathy (hypertrophic osteodytrophy) during active disease and remission
Serum levels of innate immunity cytokines are elevated in dogs with metaphyseal osteopathy (hypertrophic osteodytrophy) during active disease and remission
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DOI：
10.1016/j.vetimm.2016.08.003
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发表时间：
2016-10-15
影响因子：
1.8
通讯作者：
Bannasch, Danika L.
中科院分区：
文献类型：
--
作者：
Safra, Noa;Hitchens, Peta L.;Bannasch, Danika L.
干骺端骨病(MO)(肥大性骨营养不良)是一种原因不明的发育障碍，影响狗的快速生长。受影响的狗会反复发作松解性/硬化性干骺端病变和全身性炎症。MO在普通犬中很少见；然而，一些品种(魏玛拉纳犬、大丹犬和爱尔兰赛特犬)的发病率要高得多，这支持了一种遗传病因学。平行表现的儿童自身炎症性疾病，如慢性复发性多灶性骨髓炎(CRMO)和白介素1受体拮抗剂(DIRA)缺乏，涉及先天免疫途径受损和细胞因子的异常产生。鉴于这些疾病之间的相似性，我们假设MO是一种由参与先天免疫的细胞因子介导的自体炎症性疾病。为了确定MO犬免疫紊乱的特征，我们测定了26只MO犬和102只对照犬的血清炎症标记物水平。MOG犬血清IL-1β、IL-18、IL-6、粒细胞-巨噬细胞集落刺激因子(GM-CSF)、C-X-C基序趋化因子10(CXCL10)、肿瘤坏死因子(TNF)和IL-10水平显著升高(pg/ml)。值得注意的是，恢复的MO犬在活动性MO病期间与狗没有不同，提供了一种疾病易感性的提示机制。这是第一份关于MO犬免疫标志物升高的文献，揭示了一种类似于儿童自体炎症性疾病的免疫特征。(C)2016爱思唯尔B.V.保留所有权利。
Metaphyseal osteopathy (MO) (hypertrophic osteodystrophy) is a developmental disorder of unexplained etiology affecting dogs during rapid growth. Affected dogs experience relapsing episodes of lytic/sclerotic metaphyseal lesions and systemic inflammation. MO is rare in the general dog population; however, some breeds (Weimaraner, Great Dane and Irish Setter) have a much higher incidence, supporting a hereditary etiology. Autoinflammatory childhood disorders of parallel presentation such as chronic recurrent multi focal osteomyelitis (CRMO), and deficiency of interleukin-1 receptor antagonist (DIRA), involve impaired innate immunity pathways and aberrant cytokine production. Given the similarities between these diseases, we hypothesize that MO is an autoinflammatory disease mediated by cytokines involved in innate immunity. To characterize immune dysregulation in MO dogs we measured serum levels of inflammatory markers in 26 MO and 102 control dogs. MO dogs had significantly higher levels (pg/ml) of serum Interleukin-1beta (IL-1 beta), IL-18, IL-6, Granulocyte-macrophage colony stimulating factor (GM-CSF), C-X-C motif chemokine 10 (CXCL10), tumor necrosis factor (TNF), and IL-10. Notably, recovered MO dogs were not different from dogs during active MO disease, providing a suggestive mechanism for disease predisposition. This is the first documentation of elevated immune markers in MO dogs, uncovering an immune profile similar to comparable autoinflammatory disorders in children. (C) 2016 Elsevier B.V. All rights reserved.